Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 6/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 5/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967654 | 0.88 | LTA4H (0.50) | HSD11B1DPP4ALDH1A1LMNAMAPT | |
| SCHEMBL7697264 | 0.84 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTNPSR1TAAR1 | |
| SCHEMBL27630337 | 0.80 | PRMT3 (0.44) | HSD11B1 | |
| SCHEMBL6429540 | 0.79 | HSD11B1 (0.58) | HSD11B1DPP4DAGLAABHD6PARP14 | |
| Hydrochloric Acid SCHEMBL4766854 | 0.79 | ALDH1A1 (0.57) | HSD11B1DPP4ALDH1A1LMNAMAPT | |
| SCHEMBL27492 | 0.79 | — | — | |
| SCHEMBL16908331 | 0.78 | CA1 (0.55) | DPP4 | |
| SCHEMBL8870960 | 0.78 | PRMT3 (0.53) | ALDH1A1LMNAMAPTNPSR1TAAR1 | |
| SCHEMBL7493746 | 0.78 | KDM4E (0.55) | HSD11B1ALDH1A1OPRD1PARP14 | |
| SCHEMBL12125006 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |