Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202507 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1KDM4ESLC22A1LMNA | |
| SCHEMBL6203337 | 0.80 | TDP1 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6201593 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1KDM4ELMNAEPHX2 | |
| Hydrochloric Acid SCHEMBL10525622 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1KDM4ELMNAEPHX2 | |
| SCHEMBL6322016 | 0.77 | SLC22A1 (0.62) | SMN1; SMN2ALDH1A1KDM4ESLC22A1LMNA | |
| SCHEMBL6321040 | 0.76 | HAT1 (0.54) | — | |
| SCHEMBL9740565 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14288495 | 0.75 | RAB9A (0.61) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| Benzoin SCHEMBL7056366 | 0.74 | LMNA (0.64) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6203368 | 0.73 | HDAC3 (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |