Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203484 | 0.88 | ALOX15 (0.49) | APPRELACYP1A2ALOX15 | |
| SCHEMBL6204519 | 0.79 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTCYP1A2CYP2D6 | |
| SCHEMBL6205129 | 0.79 | NFE2L2 (0.44) | CYP3A4MAPK1MAPTRELACYP1A2 | |
| SCHEMBL8340935 | 0.78 | RELA (0.40) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL8341640 | 0.76 | RELA (0.39) | KDM4EALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL29928402 | 0.76 | MAOA (0.54) | KDM4EALDH1A1SMN1; SMN2APPHTT | |
| SCHEMBL8531808 | 0.76 | APP (0.49) | KDM4EALDH1A1SMN1; SMN2TP53APP | |
| SCHEMBL21657641 | 0.76 | MAOA (0.54) | KDM4EALDH1A1SMN1; SMN2APPHTT | |
| SCHEMBL31491182 | 0.76 | APP (0.49) | KDM4EALDH1A1SMN1; SMN2TP53APP | |
| SCHEMBL5247739 | 0.76 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |