Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563502 | 0.83 | NFE2L2 (0.47) | NFE2L2MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6204519 | 0.81 | ALDH1A1 (0.42) | MAPTCYP1A2CYP2D6PKMNPC1 | |
| SCHEMBL6204705 | 0.79 | KDM4E (0.49) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL6203484 | 0.79 | ALOX15 (0.49) | NFE2L2CYP1A2CHRM5RELANQO2 | |
| SCHEMBL8340935 | 0.79 | RELA (0.40) | MAPTCYP1A2CYP2D6NPC1RAB9A | |
| SCHEMBL8341640 | 0.78 | RELA (0.39) | MAPTCYP1A2CYP2D6NPC1RAB9A | |
| SCHEMBL6204739 | 0.75 | NFE2L2 (0.49) | NFE2L2CYP1A2CYP3A4CYP2D6PKM | |
| SCHEMBL7039420 | 0.71 | NFE2L2 (0.58) | NFE2L2CYP1A2CYP3A4CYP2D6PKM | |
| SCHEMBL6205337 | 0.71 | CYP11B2 (0.41) | MAPTCYP2D6MAPK1NPC1RAB9A | |
| SCHEMBL5244736 | 0.70 | NFE2L2 (0.52) | NFE2L2CYP1A2CYP3A4CYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527046-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004009546-A1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-29 | — | — | WO | disclosed |