Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211014 | 0.91 | CTSB (0.39) | LMNASMN1; SMN2TP53GFERGAA | |
| SCHEMBL6254282 | 0.87 | CTSK (0.38) | GAACTSSCTSKKCNA5KEAP1 | |
| SCHEMBL6212092 | 0.87 | PREP (0.48) | ALDH1A1LMNASMN1; SMN2TP53GFER | |
| SCHEMBL6211554 | 0.86 | KCNA5 (0.39) | ALDH1A1LMNASMN1; SMN2TP53GFER | |
| SCHEMBL6211220 | 0.84 | CHRM4 (0.38) | ALDH1A1LMNATP53HSD17B10MMP2 | |
| SCHEMBL6210847 | 0.84 | KEAP1 (0.38) | ALDH1A1SMN1; SMN2TSHRGAAKCNA5 | |
| SCHEMBL6213622 | 0.83 | LMNA (0.38) | ALDH1A1LMNASMN1; SMN2TSHRNAMPT | |
| SCHEMBL6209651 | 0.83 | LMNA (0.42) | LMNATP53NAMPTGAAMMP3 | |
| SCHEMBL6212436 | 0.83 | LMNA (0.38) | ALDH1A1LMNATSHRHSD17B10ELOVL6 | |
| SCHEMBL6211558 | 0.83 | LMNA (0.38) | ALDH1A1LMNATSHRHSD17B10ELOVL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |