Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.38 |
| ▸ | CTSL | P07711 | 13/20 | 0.38 |
| ▸ | CTSS | P25774 | 12/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210847 | 0.89 | KEAP1 (0.38) | GAADPP8DPP7KEAP1NFE2L2 | |
| SCHEMBL6209447 | 0.87 | ALDH1A1 (0.41) | CTSKCTSSGAAKEAP1NFE2L2 | |
| SCHEMBL6211270 | 0.85 | TGM2 (0.41) | CTSKCTSLCTSSGAADPP4 | |
| SCHEMBL6211014 | 0.85 | CTSB (0.39) | CTSKCTSSGAAKCNA5 | |
| SCHEMBL6211360 | 0.84 | CHRM4 (0.40) | CTSKCTSLCTSSGAA | |
| SCHEMBL6210259 | 0.84 | MEN1 (0.38) | CTSKCTSLCTSSDPP4 | |
| SCHEMBL6211016 | 0.83 | CTSK (0.37) | CTSKCTSLCTSS | |
| SCHEMBL6213254 | 0.82 | CTSK (0.44) | CTSKCTSLCTSS | |
| SCHEMBL6210934 | 0.82 | CTSK (0.44) | CTSKCTSLCTSSGAA | |
| SCHEMBL6211626 | 0.82 | CCR5 (0.38) | CTSKCTSLCTSSDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |