Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692131 | 0.80 | ALDH1A1 (0.47) | TRPV4L3MBTL1ALDH1A1GAAGFER | |
| SCHEMBL11348441 | 0.80 | TRPV4 (0.41) | TRPV4L3MBTL1ALDH1A1GAAPDIA6 | |
| SCHEMBL1199760 | 0.78 | TRPV4 (0.58) | TRPV4L3MBTL1ALDH1A1GAACDK1 | |
| SCHEMBL11792843 | 0.78 | TDP1 (0.42) | TRPV4L3MBTL1ALDH1A1GAAPDIA6 | |
| SCHEMBL29948957 | 0.78 | TRPV4 (0.58) | TRPV4L3MBTL1ALDH1A1GAACDK1 | |
| SCHEMBL310277 | 0.77 | CA1 (0.49) | TRPV4L3MBTL1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6400195 | 0.77 | CA1 (0.42) | TRPV4L3MBTL1ALDH1A1GAAPOLB | |
| SCHEMBL29764212 | 0.77 | TSHR (0.47) | TRPV4L3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL181280 | 0.77 | TSHR (0.47) | TRPV4L3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL30200885 | 0.77 | CA1 (0.49) | TRPV4L3MBTL1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507763-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097607-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |