Sugi Predict

Sugi Predict / Compounds / SCHEMBL181280

SCHEMBL181280

SCHEMBL181280

Cc1cc(F)ccc1S(=O)(=O)Cl

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ RXFP1 Q9HBX9 1/20 0.47
▸ MCL1 Q07820 1/20 0.46
▸ KMT2A Q03164 3/20 0.41
▸ MEN1 O00255 2/20 0.41
▸ TRPV4 Q9HBA0 2/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ GRM4 Q14833 1/20 0.38
▸ EPHX2 P34913 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ PKM P14618 1/20 0.37
▸ MEP1B Q16820 1/20 0.37
▸ LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29764212 1.00 TSHR (0.47) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL533075 0.83 KMT2A (0.51) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL31674581 0.83 KMT2A (0.51) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL2122256 0.83 TSHR (0.50) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL896792 0.83 TSHR (0.50) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL2241501 0.82 KDM4E (0.42) KMT2AMEN1ALDH1A1LMNA
SCHEMBL4618409 0.81 TSHR (0.49) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL4572915 0.81 L3MBTL1 (0.59) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL5565043 0.80 KMT2A (0.40) TSHRMAPK1RXFP1MCL1KMT2A
SCHEMBL6038470 0.79 TSHR (0.47) TSHRMAPK1RXFP1MCL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114555555-B Process for preparing 1,1' -disulfanediylbis (4-fluoro-2-methyl-5-nitrobenzene) 拜耳公司 2024-03-01 — — CN claimed
US-20220348538-A1 PROCESS OF PREPARING 1,1'-DISULFANDIYLBIS(4-FLUORO-2-METHYL-5-NITROBENZOL) BAYER AKTIENGESELLSCHAFT (DE) 2022-11-03 — — US claimed
EP-4045482-A1 PROCESS OF PREPARING 1,1'-DISULFANDIYLBIS(4-FLUORO-2-METHYL-5-NITROBENZOL) Bayer Aktiengesellschaft (DE) 2022-08-24 — — EP claimed
CN-114555555-A Process for preparing 1, 1' -dithioalkanediyl bis (4-fluoro-2-methyl-5-nitrobenzene) 拜耳公司 2022-05-27 — — CN claimed
WO-2021074108-A1 PROCESS OF PREPARING 1,1'-DISULFANDIYLBIS(4-FLUORO-2-METHYL-5-NITROBENZOL) BAYER AKTIENGESELLSCHAFT (DE) 2021-04-22 — — WO claimed
CN-104678028-A Pretreatment and detection method for biogen amine neurotransmitter and detection kit INST PHARM & TOXICOLOGY AMMS 2015-06-03 — — CN claimed
WO-2026104681-A1 NEW SULFONAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2026-05-21 — — WO disclosed
EP-3735975-B1 ERTUGLIFLOZIN FOR USE IN TREATING HEART FAILURE IN PATIENTS WITH DIABETES MERCK SHARP & DOHME LLC (US) 2025-12-03 — — EP disclosed
US-20250250265-A1 BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF NACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D VANDERBILT UNIVERSITY 2025-08-07 — — US disclosed
CN-120398732-A Synthesis method of thioether compound 南京药元生物医药科技有限公司 2025-08-01 — — CN disclosed
CN-120005077-A Polyacid polymer and preparation method and application thereof 佛山绿动氢能科技有限公司 2025-05-16 — — CN disclosed
CN-119977905-A Green synthesis method of saccharin and saccharin derivative 湖南科技大学 2025-05-13 — — CN disclosed
CN-119118894-A TRPV4 receptor ligands 犹他大学研究基金会 2024-12-13 — — CN disclosed
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof WYETH (US) 2006-12-07 — — US disclosed
WO-2006124875-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF WYETH (US) 2006-11-23 — — WO disclosed
US-20060199816-A1 Aryl sulfonyl piperidines GILLESPIE PAUL 2006-09-07 — — US disclosed
US-20050049286-A1 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists ENCYSIVE PHARMACEUTICALS INC. 2005-03-03 — — US disclosed
US-20040180892-A1 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists ENCYSIVE PHARMACEUTICALS INC. 2004-09-16 — — US disclosed
WO-2000066562-A1 PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-11-09 — — WO disclosed
US-5795892-A ANTICOAGULANTS BOEHRINGER MANNEIM GMBH (DE) 1998-08-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250250265-A1 BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF NACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D PLD1, PLD2, NAPEPLD TSHR 3720/4885MAPK1 3420/4885RXFP1 3268/4885
US-20060199816-A1 Aryl sulfonyl piperidines GPR119, SLC5A2, GLS2 TSHR 761/4885MAPK1 2294/4885RXFP1 2782/4885
US-20050049286-A1 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists CCR9, CCR1, CCRL2 TSHR 1741/4885MAPK1 2363/4885RXFP1 477/4885
US-20040180892-A1 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists CCR9, CCR1, CCRL2 TSHR 1741/4885MAPK1 2363/4885RXFP1 477/4885
US-20220348538-A1 PROCESS OF PREPARING 1,1'-DISULFANDIYLBIS(4-FLUORO-2-METHYL-5-NITROBENZOL) DDT, PFAS, DNPH1 TSHR 4639/4885MAPK1 1474/4885RXFP1 4801/4885
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof SFRP1, SOS1, FZD7 TSHR 3611/4885MAPK1 934/4885RXFP1 920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.