Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217295 | 0.99 | THRB (0.47) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT | |
| Hydrochloric Acid SCHEMBL6214006 | 0.90 | SMN1; SMN2 (0.53) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT | |
| SCHEMBL6213516 | 0.89 | SMN1; SMN2 (0.54) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT | |
| Hydrochloric Acid SCHEMBL6212921 | 0.83 | MAPT (0.47) | THRBSMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL6212229 | 0.83 | L3MBTL1 (0.43) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT | |
| Hydrochloric Acid SCHEMBL6214106 | 0.80 | SMN1; SMN2 (0.51) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT | |
| SCHEMBL6218151 | 0.79 | SMN1; SMN2 (0.52) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT | |
| Hydrochloric Acid SCHEMBL6215660 | 0.76 | KDM4E (0.42) | THRBSMN1; SMN2L3MBTL1MAPTHTT | |
| Hydrochloric Acid SCHEMBL6217542 | 0.76 | ALDH1A1 (0.51) | THRBSMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL3887478 | 0.76 | SMN1; SMN2 (0.56) | THRBSMN1; SMN2L3MBTL1TRPV1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129690-B1 | Keratin fibre dye compositions containing indolizine cationic derivatives and dyeing method | OREAL (FR) | 2005-01-05 | — | — | EP | claimed |
| US-6579326-B2 | For dyeing hair | L'OREAL S.A. (FR) | 2003-06-17 | — | — | US | claimed |
| US-20030028975-A9 | COMPOSITIONS FOR DYEING KERATIN FIBERS, CONTAINING CATIONIC INDOLIZINE DERIVATIVES, AND DYEING PROCESS | L'OREAL S.A. (FR) | 2003-02-13 | — | — | US | claimed |
| US-20010044974-A1 | Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process | BRETON PHILIPPE (FR) | 2001-11-29 | — | — | US | claimed |
| US-6579326-B2 | For dyeing hair | L'OREAL S.A. (FR) | 2003-06-17 | — | — | US | disclosed |
| US-20030028975-A9 | COMPOSITIONS FOR DYEING KERATIN FIBERS, CONTAINING CATIONIC INDOLIZINE DERIVATIVES, AND DYEING PROCESS | L'OREAL S.A. (FR) | 2003-02-13 | — | — | US | disclosed |
| US-20010044974-A1 | Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process | BRETON PHILIPPE (FR) | 2001-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044974-A1 | Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process | KRT18, INMT, KMO | THRB 4083/4885SMN1; SMN2 4471/4885L3MBTL1 4827/4885 |
| US-20030028975-A9 | COMPOSITIONS FOR DYEING KERATIN FIBERS, CONTAINING CATIONIC INDOLIZINE DERIVATIVES, AND DYEING PROCESS | KRT18, INMT, KMO | THRB 4046/4885SMN1; SMN2 4639/4885L3MBTL1 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.