Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6248461 | 0.99 | DRD2 (0.46) | DRD2HTR2AHTR7HTR1AHTR2C | |
| SCHEMBL5767981 | 0.88 | KDR (0.47) | HTR2AHTR1AHTR2CKDRHRH4 | |
| Hydrochloric Acid SCHEMBL1963879 | 0.87 | KDR (0.46) | HTR2AHTR1AHTR2CKDRHRH4 | |
| SCHEMBL531012 | 0.85 | ACHE (0.52) | DRD2HTR2AHTR7HTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL14128737 | 0.84 | ACHE (0.51) | DRD2HTR2AHTR7HTR1AHTR2C | |
| SCHEMBL6219432 | 0.82 | HTR2C (0.44) | HTR1AHTR2CKCNH2HRH4CHRNA7 | |
| SCHEMBL13902828 | 0.82 | ESR1 (0.45) | HTR2C | |
| SCHEMBL1840383 | 0.82 | HRH4 (0.48) | HTR2AHTR7HTR1AHTR2CSLC6A4 | |
| Bromide SCHEMBL3899882 | 0.81 | ESR1 (0.44) | HTR2C | |
| SCHEMBL13448255 | 0.79 | HTR2A (0.60) | DRD2HTR2AHTR7HTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098034-A1 | 2H-BENZOTRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | ORXES THERAPEUTICS CO LTD (CN) | 2026-04-09 | — | — | US | disclosed |
| EP-4592287-A1 | 2H-BENZOTRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Orxes Therapeutics Co., Ltd. (CN) | 2025-07-30 | — | — | EP | disclosed |
| CN-115304590-B | 2H-benzotriazole derivatives, preparation method thereof and pharmaceutical composition containing same | 皮摩尔新药(辽宁)有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-115381827-B | Application of benzotriazole derivative in preparation of medicine for treating or preventing cardiovascular diseases | 皮摩尔新药(辽宁)有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115381827-A | Application of benzotriazole alkyl derivative in preparation of medicine for treating or preventing cardiovascular diseases | 皮摩尔新药(辽宁)有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115304590-A | 2H-benzotriazole derivatives, preparation method thereof and pharmaceutical composition containing same | 皮摩尔新药(辽宁)有限公司 | 2022-11-08 | — | — | CN | disclosed |
| US-9802929-B2 | Benzo five-membered nitrogen heterocyclic piperidine or piperazine derivatives and preparation methods and pharmaceutical compositions thereof | SHENYANG HAIWANG BIOTECHNOLOGY CO., LTD. (CN) | 2017-10-31 | — | — | US | disclosed |
| US-9415047-B2 | Use of benzo five-membered nitrogen heterocyclic piperazine or piperidine derivatives | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2016-08-16 | — | — | US | disclosed |
| US-20160009703-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERIDINE OR PIPERAZINE DERIVATIVES AND PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS THEREOF | LIAONING EMMY BIOLOGICAL PHARMACEUTICAL CO., LTD (CN) | 2016-01-14 | — | — | US | disclosed |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2015-10-22 | — | — | US | disclosed |
| EP-0811622-B1 | 3-(Piperid-4-yl)-1,2-benzisoxazole and 3-(piperazin-4-yl)-1,2-benzisoxazole derivatives as antipsychotics | ADIR (FR) | 2000-05-10 | — | — | EP | disclosed |
| EP-0971926-A1 | DIHYDROPYRAZINO 1,2-$i(A)-]INDOLE-1-ONE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042710-A1 | DIHYDROPYRAZINO [1,2-A-]INDOLE-1-ONE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |
| US-5780474-A | ADMINISTERING IN THE TREATMENT OF PSYCHOTIC DISORDERS, ANXIO-DEPRESSIVE DISORDERS AND AGGRESSIVENESS | ADIR ET COMPAGNIE (FR) | 1998-07-14 | — | — | US | disclosed |
| CN-1171401-A | New 3-(piperid-4-yl)-1, 2 -benzisoxazole and 3-(piperazin-4-yl) -1, 2-benzisoxazole compounds, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-01-28 | — | — | CN | disclosed |
| EP-0811622-A1 | 3-(Piperi-4-yl) 1,2-benzisoxazole and 3-(piperazin-4-yl) 1,2-benzisoxazole derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-12-10 | — | — | EP | disclosed |
| EP-0494817-B1 | Benzisoxazole and benzisothiazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-09-06 | — | — | EP | disclosed |
| US-5173490-A | Antipsychotic drugs having no side effects; anxiolytic agents; analgesics; tranquilizers; sedatives; antidepressants | ADIR ET COMPAGNIE (FR) | 1992-12-22 | — | — | US | disclosed |
| EP-0494817-A1 | Benzisoxazole and benzisothiazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-07-15 | — | — | EP | disclosed |
| CN-1048037-A | N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, their preparation and their use as pharmaceuticals | HOECHST ROUSSEL PHARMA (US) | 1990-12-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | P2RX5, TBXA2R, CYP3A5 | DRD2 445/4885HTR2A 353/4885HTR7 577/4885 |
| US-20260098034-A1 | 2H-BENZOTRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SLC6A11, SLC6A1, GABRQ | DRD2 417/4885HTR2A 266/4885HTR7 14/4885 |
| US-20160009703-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERIDINE OR PIPERAZINE DERIVATIVES AND PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS THEREOF | CYP3A5, IL5, ABCC5 | DRD2 725/4885HTR2A 521/4885HTR7 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.