Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1068501 | 0.98 | RAB9A (0.38) | TSHRCYP3A4PIK3CARAB9ATP53 | |
| SCHEMBL1067214 | 0.77 | NPSR1 (0.52) | TSHRRAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL8298290 | 0.76 | CYP3A4 (0.52) | TSHRCYP3A4PIK3CAALDH1A1HSD17B10 | |
| SCHEMBL4173702 | 0.74 | RAB9A (0.38) | TSHRCYP3A4RAB9ATP53HSD17B10 | |
| SCHEMBL27608342 | 0.72 | ACHE (0.40) | TSHRCYP3A4PIK3CARAB9AALDH1A1 | |
| SCHEMBL13915601 | 0.72 | LMNA (0.42) | RAB9AALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL907658 | 0.71 | ACHE (0.61) | TSHRCYP3A4PIK3CARAB9AALDH1A1 | |
| SCHEMBL14747768 | 0.71 | ALDH1A1 (0.49) | TSHRRAB9ATP53ALDH1A1LMNA | |
| SCHEMBL1706851 | 0.70 | LMNA (0.45) | CYP3A4RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL30258790 | 0.69 | ALDH1A1 (0.62) | TSHRCYP3A4PIK3CATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987256-B2 | Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-8987256-B2 | Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |
| US-20110034450-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIEGESELLSCHAFT (DE) | 2011-02-10 | — | — | US | disclosed |
| US-20110034450-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIEGESELLSCHAFT (DE) | 2011-02-10 | — | — | US | disclosed |
| WO-2009127338-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-10-22 | — | — | WO | disclosed |
| EP-1597257-A1 | OXAZOLE-DERIVATIVES AS PPAR AGONISTS | PFIZER INC. (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20040209929-A1 | Fused heteroaryl carboxylic acids as PPAR agonists | AGOURON PHARMACEUTICALS, INC. | 2004-10-21 | — | — | US | disclosed |
| WO-2004074284-A1 | OXAZOLE-DERIVATIVES AS PPAR AGONISTS | PFIZER INC. (US) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034450-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF | OTC, PC, HCAR2 | TSHR 3706/4885CYP3A4 210/4885PIK3CA 1522/4885 |
| US-20040209929-A1 | Fused heteroaryl carboxylic acids as PPAR agonists | PPARG, PPARA, PPARD | TSHR 444/4885CYP3A4 411/4885PIK3CA 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.