Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896665 | 0.81 | TSHR (0.55) | KDM4EALDH1A1HTTTDP1HPGD | |
| Bromide SCHEMBL30583587 | 0.81 | BCHE (0.62) | KDM4EALDH1A1MAOBMEN1KMT2A | |
| SCHEMBL1301847 | 0.78 | LOXL2 (0.58) | KDM4EALDH1A1HTTTDP1HPGD | |
| SCHEMBL1218850 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HTTTDP1HPGD | |
| SCHEMBL81395 | 0.78 | TTR (0.54) | KDM4EALDH1A1HTTTDP1HPGD | |
| SCHEMBL23312282 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1HTTTDP1HPGD | |
| SCHEMBL1352681 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HTTTDP1HPGD | |
| SCHEMBL202774 | 0.78 | ALDH1A1 (0.54) | KDM4EALDH1A1HTTTDP1HPGD | |
| Bromide SCHEMBL3939438 | 0.78 | TAAR1 (0.58) | ALDH1A1MAOB | |
| SCHEMBL1329916 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HTTTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1200922-C | Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds | BASF AG (DE) | 2005-05-11 | — | — | CN | disclosed |
| EP-1358143-B1 | PROCESS AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PESTICIDAL FLUOROOLEFIN COMPOUNDS | BASF AG (DE) | 2005-04-13 | — | — | EP | disclosed |
| US-6770788-B2 | REACTING A SUBSTITUTED 1-BROMO-1-FLUORO-3-ARYL-1-PROPENE AN ARYLMETHYL ZINC COMPOUND IN THE PRESENCE OF A PALLADIUM CATALYST AND A SOLVENT | BASF AKTIENGESELLSCHAFT (DE) | 2004-08-03 | — | — | US | disclosed |
| CN-1468206-A | Process and intermediate compounds for preparing pesticidal fluoroolefin compounds | �����ɷ� | 2004-01-14 | — | — | CN | disclosed |
| EP-1358143-A2 | PROCESS AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PESTICIDAL FLUOROOLEFIN COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2003-11-05 | — | — | EP | disclosed |
| US-20030135075-A1 | Process and intermediate compounds for preparation of pesticidal fluoroolefin compounds | WOOD WILLIAM WAKEFIELD (US) | 2003-07-17 | — | — | US | disclosed |
| US-6495728-B2 | ARALKYLATION OF A FLUOROBROMOOLEFIN WITH AN ARALKYLZINC BROMIDE OR BIS(ARALKYL)ZINC IN PRESENCE OF A PALLADIUM CATALYST; PREPARATION OF THE OLEFIN FROM AN ALDEHYDE AND CBR3F, A PHOSPHINE OR PHOSPHORAMIDE AND ZINC | BASF AKTIENGESELLSCHAFT (DE) | 2002-12-17 | — | — | US | disclosed |
| US-20020062049-A1 | Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds | BASF AKTIENGESELLSCHAFT | 2002-05-23 | — | — | US | disclosed |
| WO-2002022538-A2 | PROCESS AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PESTICIDAL FLUOROOLEFIN COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030135075-A1 | Process and intermediate compounds for preparation of pesticidal fluoroolefin compounds | DDT, AHR, CYP2F1 | KDM4E 1766/4885ALDH1A1 309/4885HTT 2436/4885 |
| US-20020062049-A1 | Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds | DDT, PFAS, CYP2F1 | KDM4E 1506/4885ALDH1A1 132/4885HTT 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.