Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.36 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235020 | 0.84 | NOTUM (0.48) | SIRT6ARSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL6240445 | 0.82 | NOTUM (0.49) | USP30PHGDHSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21448004 | 0.81 | SIRT6 (0.61) | SIRT6ALKBH5ADRB1SMN1; SMN2MEN1 | |
| SCHEMBL13122994 | 0.81 | AR (0.49) | SIRT6ARALKBH5ADRB1SMN1; SMN2 | |
| SCHEMBL28166708 | 0.80 | AR (0.48) | SIRT6ARALKBH5ADRB1SMN1; SMN2 | |
| SCHEMBL30822010 | 0.77 | MAPT (0.49) | SIRT6SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL12059104 | 0.77 | MAPT (0.49) | SIRT6SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL11627069 | 0.77 | ADRB1 (0.65) | ALKBH5ADRB1MAPTHTR2CALDH1A1 | |
| SCHEMBL6237643 | 0.74 | CA2 (0.51) | USP30PHGDHCYP3A4HTR2AKDM4E | |
| SCHEMBL3712914 | 0.73 | ALDH1A1 (0.60) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |