Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 14/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240445 | 0.84 | NOTUM (0.49) | NOTUMTP53MAPTCYP1A2CYP3A4 | |
| SCHEMBL6233708 | 0.84 | USP30 (0.44) | ARSIRT6KDM4ETP53MAPT | |
| SCHEMBL6238899 | 0.79 | NOTUM (0.55) | NOTUMARKDM4E | |
| SCHEMBL11453106 | 0.76 | NOTUM (0.51) | NOTUMARSIRT6RXRAGRIN1 | |
| SCHEMBL2928855 | 0.76 | HTR3E (0.55) | NOTUMARTP53MAPTCYP1A2 | |
| SCHEMBL6237643 | 0.76 | CA2 (0.51) | NOTUMKDM4ETP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL2276790 | 0.75 | THRB (0.56) | NOTUMARTP53MAPTCYP1A2 | |
| SCHEMBL5375116 | 0.75 | NOTUM (0.60) | NOTUMARSIRT6SMN1; SMN2 | |
| SCHEMBL3712914 | 0.74 | ALDH1A1 (0.60) | TP53MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2928767 | 0.74 | DRD2 (0.50) | NOTUMARSIRT6KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |