Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 9/20 | 0.36 |
| ▸ | DRD4 | P21917 | 9/20 | 0.36 |
| ▸ | DRD3 | P35462 | 9/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233572 | 0.90 | ALDH1A1 (0.38) | ALDH1A1ATAD2DRD2DRD4DRD3 | |
| SCHEMBL5393583 | 0.83 | DRD2 (0.52) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL8553992 | 0.81 | ATAD2 (0.55) | ALDH1A1ATAD2DRD2DRD4DRD3 | |
| SCHEMBL6712978 | 0.80 | DRD2 (0.43) | ALDH1A1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL6715173 | 0.80 | MEN1 (0.47) | ATAD2DRD2DRD4DRD3CHRM2 | |
| SCHEMBL6238530 | 0.80 | NOTUM (0.40) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL11195613 | 0.79 | DRD2 (0.47) | ATAD2DRD2DRD4DRD3CHRM2 | |
| SCHEMBL6232182 | 0.79 | LMNA (0.47) | ALDH1A1MAPT | |
| SCHEMBL6713240 | 0.79 | CHRM2 (0.39) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6714706 | 0.78 | LMNA (0.43) | ALDH1A1TP53MAPTHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | claimed |
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-14 | — | — | US | claimed |
| WO-2004089903-A9 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER LAMBERT CO (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | disclosed |
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | REN, ACE, HPN | ALDH1A1 921/4885ATAD2 363/4885DRD2 830/4885 |
| US-20040214832-A1 | Piperazine derivative renin inhibitors | REN, ACE, AGTR2 | ALDH1A1 1486/4885ATAD2 611/4885DRD2 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.