Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.43 |
| ▸ | DRD4 | P21917 | 11/20 | 0.43 |
| ▸ | DRD3 | P35462 | 11/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 10/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 10/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6715236 | 0.90 | DRD2 (0.42) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL11195613 | 0.82 | DRD2 (0.47) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL8553992 | 0.81 | ATAD2 (0.55) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL6238530 | 0.80 | NOTUM (0.40) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL6235136 | 0.80 | ALDH1A1 (0.38) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL6714706 | 0.78 | LMNA (0.43) | HPGDALDH1A1MAPT | |
| SCHEMBL89081 | 0.77 | TSHR (0.47) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL13316488 | 0.77 | SMN1; SMN2 (0.55) | HPGDHTTSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8265234 | 0.76 | ATAD2 (0.50) | DRD2DRD4DRD3CHRM2CHRM4 | |
| SCHEMBL6721467 | 0.76 | GRIN1 (0.42) | DRD2DRD4DRD3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | claimed |
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-14 | — | — | US | claimed |
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | disclosed |
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | REN, ACE, HPN | DRD2 830/4885DRD4 1906/4885DRD3 1151/4885 |
| US-20040214832-A1 | Piperazine derivative renin inhibitors | REN, ACE, AGTR2 | DRD2 2820/4885DRD4 3854/4885DRD3 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.