SCHEMBL6243724

SCHEMBL6243724

COC(=O)Nc1cc(Oc2ccccc2O)c(Cl)cc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK39 Q9UEW8 1/20 0.43
POLB P06746 1/20 0.43
KDM4E B2RXH2 5/20 0.42
KMT2A Q03164 4/20 0.42
ALDH1A1 P00352 2/20 0.42
NPC1 O15118 5/20 0.41
RAB9A P51151 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 4/20 0.40
MEN1 O00255 3/20 0.40
MAPK1 P28482 1/20 0.40
NOD2 Q9HC29 1/20 0.40
LMNA P02545 2/20 0.40
HPGD P15428 2/20 0.40
TSHR P16473 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HTT P42858 1/20 0.40
SCN9A Q15858 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6244635 0.89 ESRRA (0.44) STK39POLBKDM4EKMT2AALDH1A1
SCHEMBL6245689 0.82 SMN1; SMN2 (0.46) POLBKDM4EALDH1A1NPC1RAB9A
SCHEMBL8076425 0.78 HPGD (0.42) POLBKDM4EKMT2AALDH1A1NPC1
SCHEMBL8760807 0.77 POLB (0.43) POLBKDM4EKMT2AALDH1A1NPC1
SCHEMBL7577594 0.75 ESRRA (0.44) POLBKDM4EKMT2AALDH1A1NPC1
SCHEMBL6248183 0.73 CA1 (0.43) POLBKDM4EKMT2AALDH1A1NPC1
SCHEMBL13397607 0.73 LMNA (0.47) POLBKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL6241694 0.73 L3MBTL1 (0.46) POLBKMT2AALDH1A1SMN1; SMN2MAPT
SCHEMBL6246195 0.73 SLC6A2 (0.40) STK39POLBKDM4EKMT2AALDH1A1
SCHEMBL3248025 0.71 TDP1 (0.44) POLBKDM4ERAB9ASMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1106607-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2005-07-27 EP disclosed
US-6667413-B2 Aniline derivatives; herbicides; nonphytotoxic SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-23 US disclosed
US-20030130124-A1 Herbicides SUMITOMO CHEMICAL COMPANY, LIMITED 2003-07-10 US disclosed
US-6451740-B2 HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-09-17 US disclosed
US-20020013466-A1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-31 US disclosed
EP-1106607-A2 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030130124-A1 Herbicides CBR3, CBR1, MT-CO1 STK39 3189/4885POLB 950/4885KDM4E 1554/4885
US-20020013466-A1 Uracil compounds and use thereof UNG, MRM1, OGG1 STK39 3827/4885POLB 207/4885KDM4E 1857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.