SCHEMBL6244635

SCHEMBL6244635

CC(=O)Nc1cc(Oc2ccccc2O)c(Cl)cc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESRRA P11474 2/20 0.44
STK39 Q9UEW8 1/20 0.44
DHODH Q02127 1/20 0.43
NPC1 O15118 4/20 0.41
RAB9A P51151 3/20 0.41
POLB P06746 1/20 0.41
ALDH1A1 P00352 3/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
KMT2A Q03164 3/20 0.40
KDM4E B2RXH2 3/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
SCN9A Q15858 1/20 0.39
MEN1 O00255 2/20 0.39
APOBEC3A P31941 1/20 0.39
GFER P55789 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6243724 0.89 STK39 (0.43) STK39NPC1RAB9APOLBALDH1A1
SCHEMBL7577594 0.86 ESRRA (0.44) ESRRADHODHNPC1RAB9APOLB
SCHEMBL6248183 0.85 CA1 (0.43) NPC1RAB9APOLBALDH1A1KMT2A
SCHEMBL3248025 0.82 TDP1 (0.44) ESRRARAB9APOLBTSHRL3MBTL1
SCHEMBL13397607 0.81 LMNA (0.47) ESRRADHODHNPC1RAB9APOLB
SCHEMBL3241043 0.81 MEN1 (0.46) RAB9APOLBALDH1A1L3MBTL1KMT2A
SCHEMBL31148975 0.81 ROCK2 (0.47) ESRRADHODHNPC1RAB9APOLB
SCHEMBL28621029 0.81 ROCK2 (0.47) ESRRADHODHNPC1RAB9APOLB
SCHEMBL9631081 0.81 MEN1 (0.44) ESRRASTK39DHODHNPC1RAB9A
SCHEMBL9633350 0.80 MEN1 (0.44) ESRRADHODHNPC1POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1276912-C Uracil compounds and use thereof SUMITOMO CHEMICAL CO (JP) 2006-09-27 CN disclosed
EP-1106607-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2005-07-27 EP disclosed
CN-1187340-C Uracil compound and use thereof SUMITOMO CHEMICAL CO (JP) 2005-02-02 CN disclosed
CN-1572786-A Uracil compounds and use thereof SUMITOMO CHEMICAL CO (JP) 2005-02-02 CN disclosed
US-6667413-B2 Aniline derivatives; herbicides; nonphytotoxic SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-23 US disclosed
US-20030130124-A1 Herbicides SUMITOMO CHEMICAL COMPANY, LIMITED 2003-07-10 US disclosed
US-6451740-B2 HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-09-17 US disclosed
US-20020013466-A1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-31 US disclosed
CN-1303852-A Uracil compound and use thereof SUMITOMO CHEMICAL CO (JP) 2001-07-18 CN disclosed
EP-1106607-A2 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030130124-A1 Herbicides CBR3, CBR1, MT-CO1 ESRRA 3362/4885STK39 3189/4885DHODH 785/4885
US-20020013466-A1 Uracil compounds and use thereof UNG, MRM1, OGG1 ESRRA 3997/4885STK39 3827/4885DHODH 754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.