Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240237 | 0.76 | ACHE (0.43) | SIRT6LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3156433 | 0.75 | SIRT6 (0.44) | SIRT6LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29089112 | 0.70 | L3MBTL1 (0.43) | SIRT6LMNAALDH1A1HTTGAA | |
| SCHEMBL7649652 | 0.70 | LMNA (0.44) | SIRT6LMNAALDH1A1CYP3A4HTT | |
| SCHEMBL427403 | 0.70 | SIRT6 (0.59) | SIRT6LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL17099539 | 0.69 | HTT (0.42) | ALDH1A1HTTGAASMN1; SMN2KMT2A | |
| SCHEMBL2312739 | 0.69 | ROCK1 (0.51) | SIRT6LMNAALDH1A1HTTGAA | |
| Hydrochloric Acid SCHEMBL5827767 | 0.69 | SIRT6 (0.58) | SIRT6LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9300572 | 0.69 | ALDH1A1 (0.58) | SIRT6LMNAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7803729 | 0.69 | HTT (0.60) | SIRT6LMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562933-A2 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS | Amgen Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004007481-A2 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATES DISORDERS | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |