SCHEMBL624840

SCHEMBL624840

FC(F)(F)c1ccc([Mg]Br)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.43
TSHR P16473 1/20 0.43
KIF11 P52732 6/20 0.42
HTR3E A5X5Y0 1/20 0.41
HTR3B O95264 1/20 0.41
PLAU P00749 1/20 0.41
HTR3A P46098 1/20 0.41
HTR3D Q70Z44 1/20 0.41
HTR3C Q8WXA8 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
ORAI1 Q96D31 1/20 0.41
ORAI2 Q96SN7 1/20 0.41
ORAI3 Q9BRQ5 1/20 0.41
TRPV6 Q9H1D0 1/20 0.41
MGLL Q99685 1/20 0.41
GSK3B P49841 2/20 0.39
PTPN1 P18031 1/20 0.39
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL63468 0.76 ALDH1A1 (0.67) ALDH1A1TSHRKIF11HTR3EHTR3B
SCHEMBL432591 0.74 CES2 (0.41) ALDH1A1TSHRCES2
SCHEMBL663624 0.74 TSHR (0.48) ALDH1A1TSHRKIF11
SCHEMBL3126195 0.74 ALDH1A1 (0.43) ALDH1A1TSHRKIF11CES2CES1
SCHEMBL16626100 0.74 ALDH1A1 (0.56) ALDH1A1TSHRKIF11HTR3EHTR3B
Bromide SCHEMBL2959626 0.72 TSHR (0.46) ALDH1A1TSHRKIF11
SCHEMBL538930 0.72 TSHR (0.48) ALDH1A1TSHRHTR3EHTR3BHTR3A
SCHEMBL11239014 0.71 ALDH1A1 (0.53) ALDH1A1TSHRKIF11HTR3EHTR3B
SCHEMBL677817 0.71 ALDH1A1 (0.53) ALDH1A1TSHRKIF11CES2CES1
SCHEMBL13205250 0.71 ALDH1A1 (0.53) ALDH1A1TSHRKIF11HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118908996-A A composition containing C (sp2) P bond or C (sp)3) Process for preparing organic phosphine compound of-P bond 烟台大学 2024-11-08 CN claimed
EP-0023093-B1 PENICILLANIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS WITH A PENICILLIN OR CEPHALOSPORIN BEECHAM GROUP PLC (GB) 1983-09-28 EP claimed
US-20260132109-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2026-05-14 US disclosed
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-20260008764-A1 BACKBONE CLEAVABLE POLYMETHACRYLATES VIA THIONOLACTONE COMONOEMERS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-01-08 US disclosed
US-12503436-B2 Compounds and compositions for treating conditions associated with STING activity NOVARTIS PHARMA AG (CH) 2025-12-23 US disclosed
EP-4587424-A1 YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS Bridgene Biosciences, Inc. (US) 2025-07-23 EP disclosed
WO-2025038673-A9 BACKBONE CLEAVABLE POLYMETHACRYLATES VIA THIONOLACTONE COMONOEMERS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2025-05-22 WO disclosed
CN-116410088-B Synthesis method of alpha-aryl propionate compound 南京工业大学 2025-05-02 CN disclosed
CN-119894866-A YAP/TAZ-TEAD oncoprotein inhibitors 布里奇恩生物科学公司 2025-04-25 CN disclosed
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors HOFFMANN-LA ROCHE INC. (US) 2025-04-22 US disclosed
US-4456761-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1984-06-26 US disclosed
US-4387230-A Process for preparing a dihydropyridine derivative JOHN WYETH AND BROTHER LIMITED (GB) 1983-06-07 US disclosed
US-4356182-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1982-10-26 US disclosed
US-4291040-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1981-09-22 US disclosed
US-4265907-A Insecticidal hydroxylamine ethers MOBIL OIL CORPORATION (US) 1981-05-05 US disclosed
US-4221744-A Hydroformylation process employing rhodium-based catalysts comprising ligands having electronegative substituents CELANESE CORPORATION (US) 1980-09-09 US disclosed
US-4152344-A CATALYSTS FOR HYDROFORMYLATION OF ALPHA-OLEFINS CELANESE CORPORATION (US) 1979-05-01 US disclosed
US-4105849-A [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines G. D. SEARLE & CO. (US) 1978-08-08 US disclosed
US-3959475-A ANTIDEPRESSANT, TRANQUILIZER, ANALGESIC AMERICAN HOECHST CORPORATION (US) 1976-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL ALDH1A1 1338/4885TSHR 1083/4885KIF11 3182/4885
US-20260132109-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, IRF3, CGAS ALDH1A1 3829/4885TSHR 3744/4885KIF11 4488/4885
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors LIPC, LPL, MGLL ALDH1A1 525/4885TSHR 1624/4885KIF11 3953/4885
US-12503436-B2 Compounds and compositions for treating conditions associated with STING activity STING1, CGAS, IRF3 ALDH1A1 4654/4885TSHR 4487/4885KIF11 4125/4885
US-20260008764-A1 BACKBONE CLEAVABLE POLYMETHACRYLATES VIA THIONOLACTONE COMONOEMERS MSRB3, SCN2B, MMAB ALDH1A1 2501/4885TSHR 441/4885KIF11 3428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.