Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9431991 | 0.84 | NPSR1 (0.40) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL8610413 | 0.81 | NPSR1 (0.43) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL9325639 | 0.72 | OPRM1 (0.46) | BRD4 | |
| SCHEMBL6250430 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL8616201 | 0.70 | KDM4E (0.39) | ALDH1A1GAALMNASMN1; SMN2MAPT | |
| SCHEMBL1990722 | 0.67 | BRD4 (0.45) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL7737588 | 0.66 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL7639950 | 0.66 | ADRA2A (0.37) | KMT2AMAPTCYP1A2 | |
| SCHEMBL8611233 | 0.66 | CYP19A1 (0.39) | — | |
| SCHEMBL8614549 | 0.66 | AKR1B1 (0.34) | MAPTGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280779-B1 | NEW POLYCYCLIC INDANYLIMIDAZOLES WITH ALPHA2 ADRENERGIC ACTIVITY | ORION CORP (FI) | 2005-08-24 | — | — | EP | disclosed |
| EP-1280779-A1 | NEW POLYCYCLIC INDANYLIMIDAZOLES WITH ALPHA2 ADRENERGIC ACTIVITY | ORION CORPORATION (FI) | 2003-02-05 | — | — | EP | disclosed |
| US-6362211-B2 | FOR THERAPY OF NEUROLOGICAL, PSYCHIATRIC OR COGNITION DISORDER, DIABETES, LIPOLYTIC DISORDER, ORTHOSTATIC HYPOTENSION, OR SEXUAL DYSFUNCTION | ORION CORPORATION (FI) | 2002-03-26 | — | — | US | disclosed |
| US-20020013356-A1 | New polycyclic indanylimidazoles with alpha2 adrenergic activity | ORION CORPORATION (FI) | 2002-01-31 | — | — | US | disclosed |
| WO-2001085698-A1 | NEW POLYCYCLIC INDANYLIMIDAZOLES WITH ALPHA2 ADRENERGIC ACTIVITY | ORION CORPORATION (FI) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013356-A1 | New polycyclic indanylimidazoles with alpha2 adrenergic activity | ADRB2, ADRB1, ADRA1A | MEN1 968/4885KMT2A 1443/4885ALDH1A1 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.