SCHEMBL625265

SCHEMBL625265

NC(=O)NCc1ccc(Br)cc1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.66
CYP2C19 P33261 1/20 0.66
TGM2 P21980 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.56
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
CA1 P00915 2/20 0.53
CA2 P00918 2/20 0.53
RECQL P46063 1/20 0.49
FPR2 P25090 3/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
TPSAB1 Q15661 2/20 0.47
ALDH1A1 P00352 2/20 0.46
LMNA P02545 1/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
FPR3 P25089 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24575914 0.83 TGM2 (0.63) TGM2L3MBTL1MEN1KMT2ACA1
SCHEMBL626651 0.81 TPSAB1 (0.70) CYP2C9CYP2C19MEN1KMT2ARECQL
SCHEMBL8139643 0.81 CYP2C9 (0.68) CYP2C9CYP2C19L3MBTL1MEN1KMT2A
SCHEMBL1694370 0.81 L3MBTL1 (0.62) CYP2C9CYP2C19TGM2L3MBTL1MEN1
SCHEMBL8245710 0.81 CYP2C9 (0.68) CYP2C9CYP2C19MEN1KMT2ARECQL
SCHEMBL27589884 0.81 CYP2C9 (0.68) CYP2C9CYP2C19MEN1KMT2ACA1
SCHEMBL26547106 0.80 TGM2 (0.47) CYP2C9CYP2C19TGM2L3MBTL1MEN1
SCHEMBL5840627 0.80 CNR1 (0.54) MEN1KMT2AFPR2ALDH1A1HPGD
SCHEMBL22466338 0.79 CYP2C9 (0.66) CYP2C9CYP2C19MEN1KMT2ACA1
SCHEMBL20715702 0.79 CYP2C9 (0.66) CYP2C9CYP2C19MEN1KMT2ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117946033-A Preparation method for photo-promoted synthesis of urea compound 兰州大学 2024-04-30 CN claimed
US-20230192646-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES UCB Biopharma SRL (BE) 2023-06-22 US claimed
EP-4081299-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES UCB Biopharma SRL (BE) 2022-11-02 EP claimed
WO-2021130255-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES UCB Biopharma SRL (BE) 2021-07-01 WO claimed
US-8729031-B2 Compounds NOVACTA BIOSYSTEMS LIMITED (GB) 2014-05-20 US claimed
EP-2393829-A1 ACTAGARDINE DERIVATIVES Novacta Biosystems Limited (GB) 2011-12-14 EP claimed
US-20110294723-A1 Compounds NOVACTA BIOSYSTEMS LIMITED (GB) 2011-12-01 US claimed
WO-2010089544-A1 ACTAGARDINE DERIVATIVES NOVACTA BIOSYSTEMS LIMITED (GB) 2010-08-12 WO claimed
WO-2025042989-A1 PSMA-BASED ALBUMIN BINDING AGENTS FOR TARGETED RADIONUCLIDE THERAPY OF PROSTATE CANCER THE JOHNS HOPKINS UNIVERSITY (US) 2025-02-27 WO disclosed
CN-117946033-A Preparation method for photo-promoted synthesis of urea compound 兰州大学 2024-04-30 CN disclosed
US-20230192646-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES UCB Biopharma SRL (BE) 2023-06-22 US disclosed
EP-4081299-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES UCB Biopharma SRL (BE) 2022-11-02 EP disclosed
WO-2021130255-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES UCB Biopharma SRL (BE) 2021-07-01 WO disclosed
CN-105283454-B Quinazoline and azepine quinazoline as RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/MTOR access double inhibitor ASANA BIOSCIENCES, LLC (US) 2019-10-29 CN disclosed
EP-2393829-A1 ACTAGARDINE DERIVATIVES Novacta Biosystems Limited (GB) 2011-12-14 EP disclosed
US-20110294723-A1 Compounds NOVACTA BIOSYSTEMS LIMITED (GB) 2011-12-01 US disclosed
WO-2010089544-A1 ACTAGARDINE DERIVATIVES NOVACTA BIOSYSTEMS LIMITED (GB) 2010-08-12 WO disclosed
US-20090233968-A1 INHIBITORS OF THE ALPHA2BETA1/GPIa-IIA INTEGRIN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2009-09-17 US disclosed
US-20090233968-A1 INHIBITORS OF THE ALPHA2BETA1/GPIa-IIA INTEGRIN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2009-09-17 US disclosed
WO-2006133338-A1 INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN THE TRUSTEES OF THE UNIVERSITY OF PENNESYLVANIA (US) 2006-12-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233968-A1 INHIBITORS OF THE ALPHA2BETA1/GPIa-IIA INTEGRIN ITGA2B, ITGB2, ITGA2 CYP2C9 2405/4885CYP2C19 2679/4885TGM2 963/4885
US-20110294723-A1 Compounds SLC11A2, SDHA, SDHB CYP2C9 102/4885CYP2C19 66/4885TGM2 2282/4885
US-20230192646-A1 DIHYDRO-CYCLOPENTA-ISOQUINOLINE DERIVATIVES FCER2, FCGR2A, FCGR1A CYP2C9 2259/4885CYP2C19 1137/4885TGM2 2149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.