Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 9/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23244939 | 0.81 | KCNH2 (0.76) | HASPINKCNH2FLT3CYP2C8CYP2C9 | |
| SCHEMBL625392 | 0.80 | F2RL3 (0.42) | THRBMAPTCHEK1 | |
| SCHEMBL624826 | 0.76 | FYN (0.60) | HASPINKCNH2FLT3LMNATHRB | |
| SCHEMBL626984 | 0.76 | PIK3CA (0.48) | HASPIN | |
| SCHEMBL23245012 | 0.74 | KCNH2 (0.62) | HASPINKCNH2FLT3CYP2C8CYP2C9 | |
| SCHEMBL29695173 | 0.74 | KCNH2 (0.62) | HASPINKCNH2FLT3CYP2C8CYP2C9 | |
| SCHEMBL625796 | 0.71 | PIK3CA (0.47) | LMNATHRBMAPTPOLBFYN | |
| SCHEMBL23288613 | 0.69 | HASPIN (0.81) | HASPINKCNH2FLT3CYP2C8CYP2C9 | |
| SCHEMBL624034 | 0.69 | LMNA (0.48) | LMNATHRBMAPTPOLBTP53 | |
| SCHEMBL27796786 | 0.68 | SLC2A1 (0.46) | CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |