Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.70 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.70 |
| ▸ | HTR3B | O95264 | 1/20 | 0.70 |
| ▸ | HTR1D | P28221 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | HTR3A | P46098 | 1/20 | 0.70 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.70 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10515108 | 0.98 | MAPT (0.71) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL12706910 | 0.98 | ALDH1A1 (0.72) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL28226906 | 0.90 | ALDH1A1 (0.77) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL232665 | 0.86 | ALDH1A1 (0.82) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| Formamide SCHEMBL7553292 | 0.85 | ALDH1A1 (0.60) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL3060543 | 0.84 | ALDH1A1 (0.88) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL4069047 | 0.84 | ALDH1A1 (0.68) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| Hydrochloric Acid SCHEMBL9311165 | 0.82 | THRB (0.88) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL11874981 | 0.82 | ALDH1A1 (0.68) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL8128832 | 0.82 | ALDH1A1 (0.50) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846676-B1 | Process for the preparation of aromatic amines from aryl chlorides | AXIVA GMBH (DE) | 2001-02-07 | — | — | EP | claimed |
| US-4259337-A | ANTIDEPRESSANTS, ANOREXIGENIC AGENTS ANTIPARKINSONIAN ACTIVITY | ROUSSEL UCLAF (FR) | 1981-03-31 | — | — | US | claimed |
| US-20250109103-A1 | (2,5-DIOXOPYRROLIDIN-1-YL)(PHENYL)-ACETAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES | UNIWERSYTET JAGIELLONSKI (PL) | 2025-04-03 | — | — | US | disclosed |
| US-12263171-B2 | 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use | MERCK SHARP & DOHME LLC (US) | 2025-04-01 | — | — | US | disclosed |
| US-12139458-B2 | (2,5-dioxopyrrolidin-1-yl)(phenyl)-acetamide derivatives and their use in the treatment of neurological diseases | UNIWERSYTET JAGIELLONSKI (PL) | 2024-11-12 | — | — | US | disclosed |
| CN-113272292-B | (2, 5-dioxopyrrolidin-1-yl) (phenyl) -acetamide derivatives and their use in the treatment of neurological diseases | 雅盖隆大学 | 2024-04-12 | — | — | CN | disclosed |
| US-20230054411-A1 | 7-, 8-, and 10-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2023-02-23 | — | — | US | disclosed |
| US-20220073461-A1 | (2,5-DIOXOPYRROLIDIN-1-YL)(PHENYL)-ACETAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES | WARSZAWSKI UNIWERSYTET MEDYCZNY (PL) | 2022-03-10 | — | — | US | disclosed |
| EP-3908580-A1 | (2,5-DIOXOPYRROLIDIN-1-YL)(PHENYL)-ACETAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES | UNIWERSYTET JAGIELLONSKI (PL) | 2021-11-17 | — | — | EP | disclosed |
| CN-113272292-A | (2, 5-dioxopyrrolidin-1-yl) (phenyl) -acetamide derivatives and their use in the treatment of neurological diseases | 雅盖隆大学 | 2021-08-17 | — | — | CN | disclosed |
| WO-2021096496-A1 | METHODS FOR FORMING ARYL CARBON-NITROGEN BONDS USING LIGHT AND PHOTOREACTORS USEFUL FOR CONDUCTING SUCH REACTIONS | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2021-05-20 | — | — | WO | disclosed |
| CN-103694163-A | Compounds as Potassium Channel Modulators | SHANGHAI SIMCERE DRUG RES CO LTD | 2014-04-02 | — | — | CN | disclosed |
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| EP-0846676-B1 | Process for the preparation of aromatic amines from aryl chlorides | AXIVA GMBH (DE) | 2001-02-07 | — | — | EP | disclosed |
| US-5831128-A | Synthesis of aromatic amines from chloroamatics | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-03 | — | — | US | disclosed |
| EP-0846676-A1 | Process for the preparation of aromatic amines from aryl chlorides | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-10 | — | — | EP | disclosed |
| EP-0372776-A2 | Arylpiperidine derivatives | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |
| US-4259337-A | ANTIDEPRESSANTS, ANOREXIGENIC AGENTS ANTIPARKINSONIAN ACTIVITY | ROUSSEL UCLAF (FR) | 1981-03-31 | — | — | US | disclosed |
| US-4259337-A | ANTIDEPRESSANTS, ANOREXIGENIC AGENTS ANTIPARKINSONIAN ACTIVITY | ROUSSEL UCLAF (FR) | 1981-03-31 | — | — | US | disclosed |
| US-4259337-A | ANTIDEPRESSANTS, ANOREXIGENIC AGENTS ANTIPARKINSONIAN ACTIVITY | ROUSSEL UCLAF (FR) | 1981-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230054411-A1 | 7-, 8-, and 10-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | ADORA2A, ADORA2B, ADORA3 | ALDH1A1 1156/4885SIGMAR1 459/4885HTR3E 77/4885 |
| US-20220073461-A1 | (2,5-DIOXOPYRROLIDIN-1-YL)(PHENYL)-ACETAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES | TRPV5, P2RX5, TRPV1 | ALDH1A1 302/4885SIGMAR1 2130/4885HTR3E 1577/4885 |
| US-12139458-B2 | (2,5-dioxopyrrolidin-1-yl)(phenyl)-acetamide derivatives and their use in the treatment of neurological diseases | TRPV5, P2RX5, TRPV1 | ALDH1A1 302/4885SIGMAR1 2130/4885HTR3E 1577/4885 |
| US-12263171-B2 | 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use | ADORA2A, ADORA2B, ADORA3 | ALDH1A1 1156/4885SIGMAR1 459/4885HTR3E 77/4885 |
| US-20250109103-A1 | (2,5-DIOXOPYRROLIDIN-1-YL)(PHENYL)-ACETAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES | TRPV5, SCN5A, P2RX5 | ALDH1A1 279/4885SIGMAR1 2239/4885HTR3E 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.