Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | CTSD | P07339 | 3/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625493 | 0.78 | PDE3B (0.43) | METAP2RXFP1LMNA | |
| SCHEMBL625999 | 0.77 | BRD4 (0.35) | DYRK1A | |
| SCHEMBL627637 | 0.74 | PDE2A (0.44) | LMNAPDE2A | |
| SCHEMBL625884 | 0.73 | PGR (0.40) | LMNA | |
| SCHEMBL625475 | 0.73 | PGR (0.57) | RXFP1LMNAMAPT | |
| SCHEMBL625825 | 0.73 | METAP2 (0.39) | METAP2RXFP1LMNAMAPTPDE2A | |
| SCHEMBL625578 | 0.72 | CHEK1 (0.36) | RXFP1LMNA | |
| SCHEMBL625682 | 0.72 | GRM2 (0.42) | LMNA | |
| SCHEMBL626022 | 0.70 | CYP11B1 (0.33) | RXFP1CYP11B2 | |
| SCHEMBL624871 | 0.70 | CSNK2A2 (0.36) | RXFP1LMNAMAPTPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |