Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 18/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627773 | 0.85 | MAPT (0.43) | MAPTLMNATHRBPOLB | |
| SCHEMBL627055 | 0.81 | MAPT (0.48) | MAPTGAALMNATHRBRXFP1 | |
| SCHEMBL627226 | 0.76 | CKS1B (0.46) | MAPT | |
| SCHEMBL627088 | 0.75 | MAPT (0.32) | MAPTTHRB | |
| SCHEMBL626887 | 0.73 | CKS1B (0.48) | MAPTTHRB | |
| SCHEMBL627999 | 0.71 | LMNA (0.41) | MAPTLMNATHRBRXFP1 | |
| SCHEMBL628100 | 0.71 | MAPT (0.54) | MAPTGAALMNATHRBPOLB | |
| SCHEMBL628253 | 0.69 | MKNK1 (0.40) | — | |
| SCHEMBL625621 | 0.69 | MAP3K12 (0.46) | MAPT | |
| SCHEMBL22216924 | 0.64 | IDO1 (0.42) | MAPTGAALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |