Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 18/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627772 | 0.75 | HRH3 (0.41) | THRBHRH3POLBLMNATP53 | |
| SCHEMBL624035 | 0.73 | SMN1; SMN2 (0.40) | MAPTLMNATP53 | |
| SCHEMBL626211 | 0.73 | IRAK1 (0.48) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL627055 | 0.73 | MAPT (0.48) | MAPTTHRBLMNA | |
| SCHEMBL627193 | 0.71 | BTK (0.46) | — | |
| SCHEMBL627088 | 0.69 | MAPT (0.32) | MAPTTHRB | |
| SCHEMBL627226 | 0.68 | CKS1B (0.46) | MAPT | |
| SCHEMBL627207 | 0.67 | OPRM1 (0.39) | — | |
| SCHEMBL627265 | 0.67 | CKS1B (0.41) | MAPTLMNA | |
| SCHEMBL627767 | 0.66 | L3MBTL1 (0.44) | MAPTHRH3POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |