Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.41 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.41 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288136 | 0.93 | PLA2G2A (0.40) | TSHRMEN1KMT2APSEN1PSEN2 | |
| SCHEMBL6279125 | 0.80 | MTNR1A (0.44) | MEN1KMT2APLA2G2APLA2G10PLA2G1B | |
| SCHEMBL3205580 | 0.78 | MEN1 (0.45) | TSHRMEN1KMT2APSEN1PSEN2 | |
| SCHEMBL20792942 | 0.78 | CASP3 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6283147 | 0.78 | PLA2G2A (0.61) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2F | |
| SCHEMBL5160095 | 0.72 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2F | |
| SCHEMBL21883681 | 0.71 | CASP3 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25136 | 0.70 | MTNR1B (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8023979 | 0.69 | MTNR1A (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3197253 | 0.69 | MAPK1 (0.50) | TSHRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930123-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-08-16 | — | — | US | disclosed |
| US-20040059130-A1 | Spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-03-25 | — | — | US | disclosed |
| EP-1349832-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002050028-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059130-A1 | Spla2 inhibitors | F2RL1, SPINT2, PLAAT2 | TSHR 4727/4885MEN1 4788/4885KMT2A 2963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.