Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.40 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.40 |
| ▸ | PLA2G2D | Q9UNK4 | 2/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284230 | 0.93 | TSHR (0.43) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL6279125 | 0.79 | MTNR1A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL6285078 | 0.78 | PLA2G2A (0.60) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL8033789 | 0.72 | ALDH1A1 (0.47) | PLA2G2ALMNAKDM4EMAPTGAA | |
| SCHEMBL3205580 | 0.71 | MEN1 (0.45) | PLA2G2ALMNAKDM4EMAPTGAA | |
| SCHEMBL5160095 | 0.71 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL6283147 | 0.71 | PLA2G2A (0.61) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL20792942 | 0.70 | CASP3 (0.52) | LMNAKDM4EMAPTGAAPKM | |
| SCHEMBL25136 | 0.70 | MTNR1B (0.60) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL8023979 | 0.69 | MTNR1A (0.46) | PLA2G2APLA2G1BLMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930123-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-08-16 | — | — | US | disclosed |
| US-20040059130-A1 | Spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-03-25 | — | — | US | disclosed |
| EP-1349832-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002050028-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059130-A1 | Spla2 inhibitors | F2RL1, SPINT2, PLAAT2 | PLA2G2A 31/4885PLA2G10 28/4885PLA2G1B 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.