Acetone

Acetone

SCHEMBL629229

CC(C)=O.NNc1ccc(C(=O)NN2C(=O)CCC2=O)cn1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.40
NNMT P40261 1/20 0.39
RAB9A P51151 2/20 0.37
HCAR3 P49019 4/20 0.37
GAA P10253 5/20 0.36
MAPT P10636 3/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
LMNA P02545 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
RXFP1 Q9HBX9 1/20 0.34
NPC1 O15118 1/20 0.34
HDAC1 Q13547 2/20 0.34
HDAC6 Q9UBN7 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetone SCHEMBL12813654 0.99 KDM4E (0.39) KDM4ENNMTRAB9AHCAR3GAA
SCHEMBL1256560 0.96 KDM4E (0.39) KDM4ENNMTRAB9AHCAR3GAA
SCHEMBL28462853 0.93 KDM4E (0.37) KDM4ENNMTRAB9AHCAR3GAA
Acetone SCHEMBL1019109 0.79 MAPK1 (0.40) KDM4ENNMTRAB9AHCAR3GAA
Acetone SCHEMBL17732269 0.78 MAPK1 (0.39) KDM4ENNMTRAB9AHCAR3GAA
SCHEMBL16767391 0.75 KDM4E (0.37) KDM4ENNMTHCAR3GAAMAPT
SCHEMBL1445644 0.74 MAPK1 (0.40) KDM4ENNMTRAB9AHCAR3GAA
SCHEMBL30914672 0.74 MAPK1 (0.40) KDM4ENNMTRAB9AHCAR3GAA
Acetone SCHEMBL7024428 0.74 HCAR3 (0.66) HCAR3
SCHEMBL2487358 0.74 NNMT (0.54) NNMTHCAR3HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010033598-A2 SYSTEM AND METHOD FOR UTILIZING MICROBUBBLES AND LIPOSOMES AS VIRAL SEQUESTERING AGENTS VERUS BIOTECHNOLOGY CORPORATION (US) 2010-03-25 WO claimed
US-20100069814-A1 SYSTEM AND METHOD FOR UTILIZING MICROBUBBLES AND LIPOSOMES AS VIRAL SEQUESTERING AGENTS VERUS BIOTECHNOLOGY CORPORATION 2010-03-18 US claimed
US-20090311698-A1 DIAGNOSTIC ASSAY WAYNE STATE UNIVERSITY 2009-12-17 US claimed
US-20240226312-A1 TREATMENT OF CANCER IN PATIENTS WITH SOLUBLE FR-ALPHA IMMUNOGEN, INC. (US) 2024-07-11 US disclosed
US-20240197898-A1 SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS IMMUNOGEN, INC. 2024-06-20 US disclosed
US-20240190956-A1 CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS IMMUNOGEN INC (US) 2024-06-13 US disclosed
US-20240182560-A1 BIPARATOPIC FR-ALPHA ANTIBODIES AND IMMUNOCONJUGATES IMMUNOGEN, INC. 2024-06-06 US disclosed
US-20240142445-A1 OPTICAL ANALYTE DETECTION SYSTEMS AND METHODS OF USE GENALYTE INC (US) 2024-05-02 US disclosed
US-RE49918-E1 Cytotoxic benzodiazepine derivatives IMMUNOGEN, INC. (US) 2024-04-16 US disclosed
US-20240050666-A1 METHODS AND DEVICES FOR MEDICAMENT DELIVERY PALO ALTO RESEARCH CENTER INCORPORATED (US) 2024-02-15 US disclosed
WO-2024035787-A2 CLAUDIN-6 ANTIBODIES AND CONJUGATES THEREOF AND USES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-02-15 WO disclosed
WO-2010118169-A2 HUMAN PROTEIN SCAFFOLD WITH CONTROLLED SERUM PHARMACOKINETICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-10-14 WO disclosed
WO-2010033598-A2 SYSTEM AND METHOD FOR UTILIZING MICROBUBBLES AND LIPOSOMES AS VIRAL SEQUESTERING AGENTS VERUS BIOTECHNOLOGY CORPORATION (US) 2010-03-25 WO disclosed
US-20100069814-A1 SYSTEM AND METHOD FOR UTILIZING MICROBUBBLES AND LIPOSOMES AS VIRAL SEQUESTERING AGENTS VERUS BIOTECHNOLOGY CORPORATION 2010-03-18 US disclosed
US-20100012880-A1 MAGNETIC PARTICLES AND METHODS OF MAKING AND USING THE SAME COLUMBUS NANOWORKS, INC. (US) 2010-01-21 US disclosed
US-20090311698-A1 DIAGNOSTIC ASSAY WAYNE STATE UNIVERSITY 2009-12-17 US disclosed
EP-2125007-A2 CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR Regents of the University of California (US) 2009-12-02 EP disclosed
EP-2062271-A2 MAGNETIC PARTICLES AND METHODS OF MAKING AND USING THE SAME Columbus Nanoworks, Inc. (US) 2009-05-27 EP disclosed
WO-2008115319-A2 CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-25 WO disclosed
WO-2008030862-A2 MAGNETIC PARTICLES AND METHODS OF MAKING AND USING THE SAME COLUMBUS NANOWORKS, INC. (US) 2008-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197898-A1 SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS MKI67, GABBR1, GABBR2 KDM4E 908/4885NNMT 3756/4885RAB9A 3371/4885
US-20240190956-A1 CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS PCNA, EPCAM, MKI67 KDM4E 1222/4885NNMT 1054/4885RAB9A 3111/4885
US-20240226312-A1 TREATMENT OF CANCER IN PATIENTS WITH SOLUBLE FR-ALPHA FOLR1, FOLR2, FRS2 KDM4E 3874/4885NNMT 3809/4885RAB9A 2549/4885
US-20240182560-A1 BIPARATOPIC FR-ALPHA ANTIBODIES AND IMMUNOCONJUGATES FOLR2, FOLR1, TFRC KDM4E 4716/4885NNMT 4593/4885RAB9A 2944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.