Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20648760 | 0.75 | KMT2A (0.46) | KMT2APKMGAAALDH1A1HGFAC | |
| SCHEMBL23122921 | 0.73 | ALDH1A1 (0.57) | KMT2AGAAALDH1A1MGLLMAPT | |
| SCHEMBL29795626 | 0.73 | ALDH1A1 (0.57) | KMT2AGAAALDH1A1MGLLMAPT | |
| SCHEMBL211182 | 0.70 | GAA (0.61) | KMT2APKMGAAALDH1A1TSHR | |
| SCHEMBL8589320 | 0.69 | MAPT (0.46) | KMT2APKMGAAALDH1A1CYP1A2 | |
| SCHEMBL20567635 | 0.69 | SCN4A (0.51) | KMT2APKMGAAALDH1A1TSHR | |
| SCHEMBL21896802 | 0.69 | SCN4A (0.50) | KMT2APKMGAAALDH1A1HGFAC | |
| SCHEMBL2748042 | 0.68 | GAA (0.62) | KMT2APKMGAAALDH1A1TSHR | |
| SCHEMBL22108809 | 0.68 | ALDH1A1 (0.55) | KMT2AGAAALDH1A1TSHRMAPT | |
| SCHEMBL9565186 | 0.67 | GAA (0.47) | KMT2APKMGAAALDH1A1HGFAC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066672-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF TEMOZOLOMIDE AND ANALOGS | CIPLA LTD (IN) | 2015-06-24 | — | — | EP | disclosed |
| US-8258294-B2 | Process for the preparation of temozolomide and analogs | CIPLA LIMITED (IN) | 2012-09-04 | — | — | US | disclosed |
| US-8232392-B2 | Process for preparing temozolomide | CHEMI S.P.A. (IT) | 2012-07-31 | — | — | US | disclosed |
| US-8232392-B2 | Process for preparing temozolomide | CHEMI S.P.A. (IT) | 2012-07-31 | — | — | US | disclosed |
| EP-2374807-A2 | An improved process for the isolation of temozolomide | CIPLA LIMITED (IN) | 2011-10-12 | — | — | EP | disclosed |
| US-20100036121-A1 | Process for preparing temozolomide | CHEMI S.P.A. (IT) | 2010-02-11 | — | — | US | disclosed |
| US-20100036121-A1 | Process for preparing temozolomide | CHEMI S.P.A. (IT) | 2010-02-11 | — | — | US | disclosed |
| US-20090326028-A1 | Process for the preparation of temozolomide and analogs | CIPLA LIMITED (IN) | 2009-12-31 | — | — | US | disclosed |
| US-7612202-B2 | Process for preparing temozolomide | CHEMAGIS, LTD. (IL) | 2009-11-03 | — | — | US | disclosed |
| US-6844434-B2 | Synthesis of temozolomide and analogs | SCHERING CORPORATION (US) | 2005-01-18 | — | — | US | disclosed |
| US-20020133006-A1 | Synthesis of temozolomide and analogs | SCHERING CORPORATION | 2002-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326028-A1 | Process for the preparation of temozolomide and analogs | IDH3A, IDH3B, IDH2 | KMT2A 683/4885PKM 1512/4885GAA 2633/4885 |
| US-20100036121-A1 | Process for preparing temozolomide | MGMT, NNMT, NOS2 | KMT2A 248/4885PKM 3064/4885GAA 3229/4885 |
| US-20020133006-A1 | Synthesis of temozolomide and analogs | MGMT, TYMS, MCL1 | KMT2A 319/4885PKM 1964/4885GAA 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.