Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185852 | 0.79 | AKT1 (0.59) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL23328518 | 0.77 | AKT1 (0.56) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL84200 | 0.77 | AKT1 (0.56) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL9422531 | 0.77 | AKT1 (0.56) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL313871 | 0.77 | AKT1 (0.56) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL108144 | 0.74 | AKT1 (0.54) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL16619964 | 0.74 | CES2 (0.52) | AKT1TSHRCES1CES2MAPT | |
| SCHEMBL3628129 | 0.74 | AKT1 (0.60) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL4467471 | 0.72 | AKT1 (0.52) | AKT1TSHRALDH1A1CES1CES2 | |
| SCHEMBL20995401 | 0.72 | AKT1 (0.52) | AKT1TSHRALDH1A1CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840549-B2 | Bisphosphonate quinolone conjugates and uses thereof | BIOVINC, LLC (US) | 2023-12-12 | — | — | US | claimed |
| US-20210369849-A1 | BONE TARGETED ANTIMICROBIAL OXAZOLIDINONE RELATED COMPOUNDS, FORMULATIONS THEREOF, AND USES THEREOF | EBETINO FRANK HALLOCK (US) | 2021-12-02 | — | — | US | claimed |
| EP-3813840-A1 | BONE TARGETED ANTIMICROBIAL OXAZOLIDINONE RELATED COMPOUNDS, FORMULATIONS THEREOF, AND USES THEREOF | Ebetino, Frank Hallock (US) | 2021-05-05 | — | — | EP | claimed |
| US-20210101920-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-04-08 | — | — | US | claimed |
| US-20190169214-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BIOVINC LLC (US) | 2019-06-06 | — | — | US | claimed |
| EP-3464307-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | Biovinc, LLC. (US) | 2019-04-10 | — | — | EP | claimed |
| WO-2017210611-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BIOVINC, LLC. (US) | 2017-12-07 | — | — | WO | claimed |
| WO-2015100423-A2 | METHODS FOR TREATING CANCER WITH GHRH AGONISTS | UNIVERSITY OF MIAMI (US) | 2015-07-02 | — | — | WO | claimed |
| US-20150174207-A1 | METHODS FOR TREATING CANCER WITH GHRH AGONISTS | UNIV MIAMI (US) | 2015-06-25 | — | — | US | claimed |
| CN-103608332-A | Pyridine-2-amides useful as CB2 agonists | HOFFMANN LA ROCHE | 2014-02-26 | — | — | CN | claimed |
| US-4956367-A | COGNITION ACTIVATORS, ALZHEIMER*S DISEASE | U C B S.A. (BE) | 1990-09-11 | — | — | US | claimed |
| EP-0183271-B1 | LYSIN DERIVATIVE AND PROTEINASE INHIBITOR | Okamoto, Shosuke (JP) | 1990-05-16 | — | — | EP | claimed |
| EP-0183271-A2 | Lysin derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1986-06-04 | — | — | EP | claimed |
| US-4558034-A | Inhibitors of bacterial collagenase | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF KENTUCKY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0076557-B1 | PEPTIDES AND PSEUDOPEPTIDES IN WHICH THE N TERMINUS BEARS TWO SUBSTITUENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-11-13 | — | — | EP | claimed |
| EP-0010661-B1 | ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-09-12 | — | — | EP | claimed |
| US-4421744-A | OPIATE RECEPTOR ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-12-20 | — | — | US | claimed |
| EP-0076557-A2 | Peptides and pseudopeptides in which the N terminus bears two substituents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-04-13 | — | — | EP | claimed |
| US-4260762-A | NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1981-04-07 | — | — | US | claimed |
| EP-0010661-A2 | Isoquinoline derivatives, process for their preparation, intermediates and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-05-14 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150174207-A1 | METHODS FOR TREATING CANCER WITH GHRH AGONISTS | GHSR, GHRHR, GNRHR | AKT1 3542/4885TSHR 61/4885ALDH1A1 1052/4885 |
| US-20190169214-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BPGM, PHPT1, NQO2 | AKT1 2297/4885TSHR 3423/4885ALDH1A1 2346/4885 |
| US-11840549-B2 | Bisphosphonate quinolone conjugates and uses thereof | BPGM, PHPT1, NQO2 | AKT1 2297/4885TSHR 3423/4885ALDH1A1 2346/4885 |
| US-20210369849-A1 | BONE TARGETED ANTIMICROBIAL OXAZOLIDINONE RELATED COMPOUNDS, FORMULATIONS THEREOF, AND USES THEREOF | SOST, BPGM, PTMS | AKT1 651/4885TSHR 3827/4885ALDH1A1 3694/4885 |
| US-20210101920-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BPGM, PHPT1, NQO2 | AKT1 2297/4885TSHR 3423/4885ALDH1A1 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.