Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314986 | 0.91 | PTGS2 (0.53) | PTGS2FAAHKCNH2PTGS1 | |
| SCHEMBL6306710 | 0.91 | FAAH (0.51) | PTGS2FAAHKCNH2PTGS1 | |
| SCHEMBL6310222 | 0.85 | ATR (0.42) | PTGS2FAAHKCNH2NR4A2RXRA | |
| SCHEMBL6309937 | 0.84 | FAAH (0.49) | PTGS2FAAHKCNH2PTGS1RXRA | |
| SCHEMBL6314926 | 0.81 | CA2 (0.43) | PTGS2PTGS1NR4A2 | |
| SCHEMBL6389506 | 0.81 | CA2 (0.43) | PTGS2PTGS1NR4A2 | |
| SCHEMBL6308696 | 0.81 | MAOB (0.49) | PTGS2FAAHKCNH2PTGS1 | |
| SCHEMBL6315385 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL6309494 | 0.81 | CA2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL8553156 | 0.79 | PTGS2 (0.68) | PTGS2FAAHKCNH2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875785-B2 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040248943-A9 | Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION | 2004-12-09 | — | — | US | disclosed |
| US-6753344-B2 | SULFONYL OR SULFONAMIDE SUBSTITUTED BENZENE DERIVATIVE CONTAINING HYDROXYUREA GROUP; USEFUL AS ANTIINFLAMMATORY AGENT | PHARMACIA CORPORATION | 2004-06-22 | — | — | US | disclosed |
| US-6696477-B2 | AS ANTIINFLAMMATORY AGENTS | PHARMACIA CORPORATION | 2004-02-24 | — | — | US | disclosed |
| US-20030176708-A1 | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION | 2003-09-18 | — | — | US | disclosed |
| US-20030119886-A1 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION | 2003-06-26 | — | — | US | disclosed |
| US-20030073722-A1 | Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION | 2003-04-17 | — | — | US | disclosed |
| US-6515014-B2 | Aminosulfonyl- or alkylsulfonylphenyl-heterocyclylalkylhydroxyamic acid or hydroxyurea derivatives; treating asthma and arthritis | G. D. SEARLE & CO. | 2003-02-04 | — | — | US | disclosed |
| US-6512121-B2 | Non-steroidal antiinflammatory agent; enzyme sub-type specific; inhibits prostaglandin and/or leukotriene production | G.D. SEARLE & CO. | 2003-01-28 | — | — | US | disclosed |
| US-6432999-B2 | ANTIINFLAMMATORY AGENTS; ANTIASTHMATIC AGENTS; ANTIPYRETICS; ANALGESICS; ANTIARTHRITIC AGENTS; ANTIISCHEMIC AGENTS | PHARMACIA CORPORATION | 2002-08-13 | — | — | US | disclosed |
| US-20020058810-A1 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | PHARMACIA CORPORATION | 2002-05-16 | — | — | US | disclosed |
| US-20020055525-A1 | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | TALLEY JOHN J (US) | 2002-05-09 | — | — | US | disclosed |
| US-20020028945-A1 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | TALLEY JOHN J (US) | 2002-03-07 | — | — | US | disclosed |
| US-20010056189-A1 | Pyrazole substituted hydroxamic acid derivatives as cyclooxxgenase-2 and 5- lipoxygenase inhibitors | TALLEY JOHN J (US) | 2001-12-27 | — | — | US | disclosed |
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028945-A1 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX12, ALOX15 | PTGS2 7/4885FAAH 94/4885KCNH2 4466/4885 |
| US-20030119886-A1 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX12, ALOX15 | PTGS2 7/4885FAAH 94/4885KCNH2 4466/4885 |
| US-20020058810-A1 | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX12, ALOX15 | PTGS2 7/4885FAAH 94/4885KCNH2 4466/4885 |
| US-20040248943-A9 | Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX15, ALOX12 | PTGS2 5/4885FAAH 195/4885KCNH2 4359/4885 |
| US-20030073722-A1 | Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX15, ALOX12 | PTGS2 5/4885FAAH 195/4885KCNH2 4359/4885 |
| US-20010056189-A1 | Pyrazole substituted hydroxamic acid derivatives as cyclooxxgenase-2 and 5- lipoxygenase inhibitors | ALOX5, ALOX15, ALOX12 | PTGS2 6/4885FAAH 187/4885KCNH2 4655/4885 |
| US-20030176708-A1 | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX15, ALOX12 | PTGS2 5/4885FAAH 144/4885KCNH2 4656/4885 |
| US-20020055525-A1 | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors | ALOX5, ALOX15, ALOX12 | PTGS2 5/4885FAAH 144/4885KCNH2 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.