Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308181 | 0.87 | TPMT (0.34) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL10965940 | 0.86 | ALDH1A1 (0.38) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL9539333 | 0.85 | CES2 (0.37) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL6648900 | 0.85 | HPGD (0.34) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL10758621 | 0.83 | L3MBTL1 (0.38) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL11042857 | 0.81 | CHRM2 (0.45) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL9556353 | 0.79 | LMNA (0.43) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL9555905 | 0.79 | THRB (0.32) | ALDH1A1CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL10828836 | 0.79 | OPRD1 (0.33) | HRH3HPGD | |
| SCHEMBL6655035 | 0.79 | MEN1 (0.37) | ALDH1A1CYP1A2MEN1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030144509-A1 | Pyrimidine derivatives and methods of making and using these derivatives | GANGJEE ALEEM (US) | 2003-07-31 | — | — | US | claimed |
| US-6221872-B1 | DEBROMINATING A PYRROLE; FUSING THE PRODUCT WITH AN AMIDINE; CONDENSING THE PRODUCT WITH A NUCLEOPHILE; REDUCING AND PURIFYING | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2001-04-24 | — | — | US | claimed |
| US-6962920-B2 | Pyrimidine derivatives and methods of making and using these derivatives | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2005-11-08 | — | — | US | disclosed |
| US-6762188-B1 | INHIBITING THYMIDYLATE SYNTHASE; COLON, BREAST OR LUNG CARCINOMA | SMITHKLINE BEECHAM CORPORATION | 2004-07-13 | — | — | US | disclosed |
| US-20040039000-A1 | Novel pyrimidine derivatives and methods of making and using these derivatives | GANGJEE ALEEM (US) | 2004-02-26 | — | — | US | disclosed |
| EP-1199307-B1 | Pharmaceutically active benzoquinazoline compounds | WELLCOME FOUND (GB) | 2004-02-25 | — | — | EP | disclosed |
| US-6696455-B1 | NITROGEN COMPOUNDS SUCH AS 6-CHLORO-2-METHYL-4-OXO-PYRIDO (3,2-D)PYRIMIDINE USED AS ANTICARCINOGENIC AGENTS AND/OR FOR PROPHYLAXIS OF INFECTIONS CAUSED BY PNEUMOCYSTIS OR TOXOPLASMA | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2004-02-24 | — | — | US | disclosed |
| US-20030144509-A1 | Pyrimidine derivatives and methods of making and using these derivatives | GANGJEE ALEEM (US) | 2003-07-31 | — | — | US | disclosed |
| US-6537999-B2 | Furopyrimidines and pyrrolopyrimidines; treating cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in immunocompromised patients. | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2003-03-25 | — | — | US | disclosed |
| US-6420370-B1 | ANTITUMOR, ANTIBIOTIC, ANTIMALARIAL, ANTIFUNGAL OR ANTIPROTOZOAL AGENTS, OR AS SYNERGISTIC AGENTS ENZYME INHIBITORS | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2002-07-16 | — | — | US | disclosed |
| US-20020052384-A1 | Novel pyrimidine derivatives and methods of making and using these derivatives | GANGJEE ALEEM (US) | 2002-05-02 | — | — | US | disclosed |
| US-4992550-A | Thymidylate synthetase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-02-12 | — | — | US | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0255228-A1 | 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1988-02-03 | — | — | EP | disclosed |
| EP-0075880-B1 | PYRIDO (2,3-D) PYRIMIDINES | Southern Research Institute (US) | 1987-07-22 | — | — | EP | disclosed |
| US-4628089-A | CHEMICAL INTERMEDIATES, ENZYME INHIBITORS, LEUKEMIA | SOUTHERN RESEARCH INSTITUTE (US) | 1986-12-09 | — | — | US | disclosed |
| US-4536575-A | INTERMEDIATES FOR 5-DEAZA ANALOGS OF FOLIC ACID, ANTICARCINOGENIC AGENTS; LEUKEMIA | SOUTHERN RESEARCH INSTITUTE (US) | 1985-08-20 | — | — | US | disclosed |
| US-4526964-A | Intermediates useful in producing 5-deaza analogs of folic acid and aminopterin | SOUTHERN RESEARCH INSTITUTE (US) | 1985-07-02 | — | — | US | disclosed |
| US-4431805-A | ANTICARCINOGENIC AGENTS; LEUKEMIA; REDUCTASE INHIBITORS; FOLIC ACID ANTAGONISTS | SOUTHERN RESEARCH INSTITUTE (US) | 1984-02-14 | — | — | US | disclosed |
| EP-0075880-A2 | Pyrido (2,3-d) pyrimidines | Southern Research Institute (US) | 1983-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039000-A1 | Novel pyrimidine derivatives and methods of making and using these derivatives | TYMP, TYMS, DPYD | ALDH1A1 1172/4885CYP1A2 986/4885MEN1 2680/4885 |
| US-20020052384-A1 | Novel pyrimidine derivatives and methods of making and using these derivatives | TYMP, TYMS, DPYD | ALDH1A1 1172/4885CYP1A2 986/4885MEN1 2680/4885 |
| US-20030144509-A1 | Pyrimidine derivatives and methods of making and using these derivatives | TYMS, TYMP, DPYD | ALDH1A1 1355/4885CYP1A2 1724/4885MEN1 1932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.