Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 11/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312493 | 0.87 | ALPL (0.50) | ALPLALPGMAPK1KMT2A | |
| SCHEMBL21775851 | 0.74 | KMO (0.42) | KMOALPLGRM2EGLN2ALPG | |
| SCHEMBL6312767 | 0.74 | KMO (0.46) | KMOALPLALPGMAPTNPSR1 | |
| SCHEMBL6320670 | 0.72 | KMO (0.36) | KMOGRM2CYP2C9EGLN2 | |
| SCHEMBL3846744 | 0.70 | KMO (0.44) | KMOALPLGRM2CYP2C9EGLN2 | |
| SCHEMBL6295365 | 0.66 | HSD11B1 (0.36) | CYP2C9EGLN2KMT2A | |
| SCHEMBL23638850 | 0.66 | S100A4 (0.46) | KMOGRM2EGLN2 | |
| SCHEMBL30598347 | 0.66 | S100A4 (0.46) | KMOGRM2EGLN2 | |
| SCHEMBL7505658 | 0.64 | HSD11B1 (0.34) | CYP2C9EGLN2KMT2A | |
| SCHEMBL9051722 | 0.64 | MAPT (0.49) | ALPLMAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219953-A1 | SULFONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-07-13 | — | — | US | disclosed |
| EP-4168392-A1 | SULFONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-26 | — | — | EP | disclosed |
| WO-2021259831-A1 | SULFONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-30 | — | — | WO | disclosed |
| CN-102863512-B | Antiviral compound | PHARMARESOURCES (SHANGHAI) CO., LTD. (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-102863512-A | Novel antiviral compound | SHANGHAI HONGBO ZHIYUAN MEDICAL TECHNOLOGY CO LTD | 2013-01-09 | — | — | CN | disclosed |
| CN-1993124-A | Substituted pyrazoles, compositions containing such compounds and methods of use | MERCK & CO INC (US) | 2007-07-04 | — | — | CN | disclosed |
| CN-1964947-A | Pyrazole derivatives, compositions containing the same and methods of use thereof | MERCK & CO INC (US) | 2007-05-16 | — | — | CN | disclosed |
| US-6897322-B2 | Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-1H-pyrazoles | BASF AKTIENGESELLSCHAFT (DE) | 2005-05-24 | — | — | US | disclosed |
| US-20040059128-A1 | Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-ih-pyrazoles | BASF AKTIENGESELLSCHAFT (DE) | 2004-03-25 | — | — | US | disclosed |
| EP-1358164-A1 | METHOD OF PRODUCING 1-ALKYL-3-ARYL-5-DIFLUOROMETHOXY-1H-PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002055504-A1 | METHOD OF PRODUCING 1-ALKYL-3-ARYL-5-DIFLUOROMETHOXY-1H-PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219953-A1 | SULFONE DERIVATIVES | SULT1E1, SULT1A1, SULT2A1 | KMO 4097/4885ALPL 3058/4885GRM2 2749/4885 |
| US-20040059128-A1 | Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-ih-pyrazoles | CYP2E1, CYP2F1, CYP1A1 | KMO 127/4885ALPL 2813/4885GRM2 2744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.