Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321996 | 1.00 | HTR2B (0.35) | HTR2BALDH1A1HPGDKDM4ECYP2D6 | |
| SCHEMBL1534233 | 0.89 | HTR2B (0.44) | HTR2BALDH1A1HPGDKDM4ECYP2D6 | |
| SCHEMBL11963386 | 0.88 | ALDH1A1 (0.37) | HTR2BALDH1A1HPGDKDM4ECYP2D6 | |
| SCHEMBL13408657 | 0.84 | PDCD1 (0.33) | — | |
| SCHEMBL6314505 | 0.84 | KDM4E (0.41) | ALDH1A1HPGDKDM4EHIF1ALMNA | |
| SCHEMBL6314507 | 0.84 | KDM4E (0.41) | ALDH1A1HPGDKDM4EHIF1ALMNA | |
| SCHEMBL3304049 | 0.82 | CA12 (0.38) | ALDH1A1HPGDKDM4EMAOACYP1A2 | |
| SCHEMBL6986273 | 0.80 | HTR2B (0.34) | HTR2BALDH1A1HPGDKDM4ECYP2D6 | |
| SCHEMBL13390599 | 0.80 | TP53 (0.36) | ALDH1A1HIF1AMAPTTSHRSMN1; SMN2 | |
| SCHEMBL6315750 | 0.80 | HTR2B (0.39) | HTR2BALDH1A1HPGDKDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570104-B2 | Metabolically programmed metal chelators and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-02-25 | — | — | US | disclosed |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-05-24 | — | — | US | disclosed |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-05-24 | — | — | US | disclosed |
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| WO-2016176343-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2016-11-03 | — | — | WO | disclosed |
| EP-2137170-B1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIV FLORIDA (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-8324397-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324397-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| EP-2137170-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115433-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA (US) | 2008-09-25 | — | — | WO | disclosed |
| US-6894170-B2 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2005-05-17 | — | — | US | disclosed |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | KRICH SYLVIA (AT) | 2005-05-12 | — | — | US | disclosed |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | HTR2B 3611/4885ALDH1A1 4405/4885HPGD 3297/4885 |
| US-10570104-B2 | Metabolically programmed metal chelators and uses thereof | FECH, SLC19A1, SLC40A1 | HTR2B 2007/4885ALDH1A1 181/4885HPGD 208/4885 |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | FECH, SLC19A1, SLC40A1 | HTR2B 2007/4885ALDH1A1 181/4885HPGD 208/4885 |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, RCOR1, MT-CO1 | HTR2B 1051/4885ALDH1A1 106/4885HPGD 1361/4885 |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | SLC40A1, HAMP, FTH1 | HTR2B 3792/4885ALDH1A1 4214/4885HPGD 3243/4885 |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, CBR3, MT-CO1 | HTR2B 1135/4885ALDH1A1 95/4885HPGD 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.