Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NPR3 | P17342 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.53 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.53 |
| ▸ | FPR2 | P25090 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | CTSS | P25774 | 3/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14902624 | 0.85 | FPR2 (0.70) | FPR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL28348563 | 0.85 | FPR2 (0.70) | FPR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5887302 | 0.84 | ITGA4 (0.64) | ITGA4ITGB7FPR2MEN1KMT2A | |
| SCHEMBL5887295 | 0.84 | ITGA4 (0.64) | ITGA4ITGB7FPR2MEN1KMT2A | |
| SCHEMBL17542476 | 0.83 | ITGA4 (0.64) | CYP3A4CYP2C8CYP2C9NPR3CYP2C19 | |
| SCHEMBL30437754 | 0.82 | NPR3 (0.55) | CYP3A4CYP2C8CYP2C9NPR3CYP2C19 | |
| SCHEMBL5887598 | 0.81 | P2RX7 (0.59) | MAPTTDP1CTSSCTSKPOLB | |
| SCHEMBL5887595 | 0.81 | P2RX7 (0.59) | MAPTTDP1CTSSCTSKPOLB | |
| SCHEMBL8445738 | 0.81 | CTSL (0.67) | ITGA4ITGB7MEN1KMT2AMAPT | |
| SCHEMBL13020623 | 0.79 | ITGA4 (0.61) | CYP3A4CYP2C8CYP2C9NPR3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887877-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2005-05-03 | — | — | US | disclosed |
| EP-1395571-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | Shire Biochem Inc. (CA) | 2004-03-10 | — | — | EP | disclosed |
| US-20030229053-A1 | Compounds and methods for the treatment or prevention of flavivirus infections | SHIRE BIOCHEM INC. (CA) | 2003-12-11 | — | — | US | disclosed |
| WO-2002100846-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | SHIRE BIOCHEM INC. (CA) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229053-A1 | Compounds and methods for the treatment or prevention of flavivirus infections | HAVCR2, ZC3HAV1, MAVS | CYP3A4 452/4885CYP2C8 451/4885CYP2C9 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.