SCHEMBL6316448

SCHEMBL6316448

CN(C(=O)OC(C)(C)C)[C@@H](CN)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.42
ITGA4 P13612 1/20 0.42
ITGB7 P26010 1/20 0.42
OPRM1 P35372 2/20 0.41
OPRD1 P41143 2/20 0.41
OPRK1 P41145 2/20 0.41
CTSS P25774 2/20 0.41
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
CTSK P43235 1/20 0.41
SLC7A5 Q01650 2/20 0.40
MMP13 P45452 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ACE P12821 1/20 0.39
REN P00797 1/20 0.39
SRR Q9GZT4 2/20 0.39
AKT1 P31749 2/20 0.39
HPGD P15428 1/20 0.38
ALPI P09923 1/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6917836 0.89 ATM (0.41) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL2014842 0.89 ATM (0.41) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL3807212 0.89 ATM (0.41) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL8907586 0.87 L3MBTL1 (0.43) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL27489128 0.87 ATM (0.43) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL2473923 0.87 ATM (0.43) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL6316889 0.87 ATM (0.43) ATMITGA4ITGB7OPRM1OPRD1
SCHEMBL22035315 0.86 ADORA1 (0.43)
SCHEMBL13010331 0.85 LDHA (0.46) OPRM1OPRD1OPRK1L3MBTL1
SCHEMBL13995754 0.85 REN (0.46) ATMITGA4ITGB7OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6939880-B2 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2005-09-06 US disclosed
EP-1565728-A1 METHOD FOR DETERMINING THE QUANTITY OF POLYMER SEPARATED FROM (METH)ACRYLIC ACID AND/OR (METH)ACRYLIC ACID ESTERS BASF AKTIENGESELLSCHAFT (DE) 2005-08-24 EP disclosed
WO-2004038391-A1 METHOD FOR DETERMINING THE QUANTITY OF POLYMER SEPARATED FROM (METH)ACRYLIC ACID AND/OR (METH)ACRYLIC ACID ESTERS BASF AKTIENGESELLSCHAFT (DE) 2004-05-06 WO disclosed
WO-2003035596-A2 INHIBITOR MIXTURE FOR (METH)ACRYLIC ACID AND (METH)ACRYLIC ACID ESTER BASF AKTIENGESELLSCHAFT (DE) 2003-05-01 WO disclosed
US-6555570-B2 Growth hormone secretagogous with improved bioavailability NOVO NORDISK A/S (DE) 2003-04-29 US disclosed
US-20030055261-A1 Compounds with growth hormone releasing properties HELSINN THERAPEUTICS (U.S.), INC. 2003-03-20 US disclosed
US-20030040483-A1 Compounds with growth hormone releasing properties HELSINN THERAPEUTICS (U.S.), INC. 2003-02-27 US disclosed
EP-1129061-A1 METHOD FOR CONTINUOUS PRODUCTION OF (METH)ACRYLIC ACID ALKYL ESTERS BASF AKTIENGESELLSCHAFT (DE) 2001-09-05 EP disclosed
US-6127391-A A PEPTIDE MIMETIC COMPOUND FOR STIMULATING THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY NOVO NORDISK A/S (DK) 2000-10-03 US disclosed
WO-2000027788-A1 METHOD FOR CONTINUOUS PRODUCTION OF (METH)ACRYLIC ACID ALKYL ESTERS BASF AKTIENGESELLSCHAFT (DE) 2000-05-18 WO disclosed
US-5977178-A Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 1999-11-02 US disclosed
EP-0869974-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1998-10-14 EP disclosed
WO-1997023508-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030055261-A1 Compounds with growth hormone releasing properties GHRHR, GHSR, IGFBP1 ATM 4618/4885ITGA4 4874/4885ITGB7 4843/4885
US-20030040483-A1 Compounds with growth hormone releasing properties GHRHR, GHSR, GRPR ATM 4668/4885ITGA4 4873/4885ITGB7 4847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.