Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Solanesol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.91 |
| ▸ | MAPT | P10636 | 2/20 | 0.91 |
| ▸ | MEN1 | O00255 | 2/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.91 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.91 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.91 |
| ▸ | SQLE | Q14534 | 7/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ICMT | O60725 | 1/20 | 0.53 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Farnesol SCHEMBL11215938 | 1.00 | KMT2A (0.91) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Farnesol SCHEMBL1549561 | 1.00 | KMT2A (0.91) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Nerol SCHEMBL5372628 | 0.98 | KMT2A (0.91) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Geraniol SCHEMBL1665820 | 0.98 | KMT2A (0.91) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Geraniol SCHEMBL8124286 | 0.98 | KMT2A (0.91) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Geraniol SCHEMBL668456 | 0.98 | KMT2A (0.91) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Geranylgeraniol SCHEMBL23814969 | 0.95 | KMT2A (1.00) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| Farnesol SCHEMBL7546574 | 0.95 | KMT2A (1.00) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL4717874 | 0.95 | KMT2A (1.00) | KMT2AMAPTMEN1CYP3A4ALOX15 | |
| SCHEMBL7944378 | 0.95 | KMT2A (1.00) | KMT2AMAPTMEN1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328654-A4 | A PRACTICAL, COST-EFFECTIVE SYNTHESIS OF COQ10 | UNIV CALIFORNIA (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20050137410-A1 | Practical, cost-effective synthesis of CoQ10 | ZYMES, INC. (US) | 2005-06-23 | — | — | US | disclosed |
| US-6852895-B2 | Oxidation of a phenol compound | ZYMES, INC. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1328654-A1 | A PRACTICAL, COST-EFFECTIVE SYNTHESIS OF COQ10 | The Regents of the University of California (US) | 2003-07-23 | — | — | EP | disclosed |
| US-20030073869-A1 | Practical, cost-effective synthesis of CoQ10 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-04-17 | — | — | US | disclosed |
| US-6545184-B1 | Electron transfer | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-04-08 | — | — | US | disclosed |
| WO-2002014530-A1 | A PRACTICAL, COST-EFFECTIVE SYNTHESIS OF COQ10 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137410-A1 | Practical, cost-effective synthesis of CoQ10 | NDUFA10, NDUFB10, NDUFS6 | KMT2A 2695/4885MAPT 3675/4885MEN1 1803/4885 |
| US-20030073869-A1 | Practical, cost-effective synthesis of CoQ10 | NDUFA10, NDUFB10, NDUFS6 | KMT2A 2695/4885MAPT 3675/4885MEN1 1803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.