Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.62 |
| ▸ | LOX | P28300 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPR39 | O43194 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20931741 | 0.86 | MEN1 (0.52) | LOXL2LOXMAOBSMN1; SMN2NPC1 | |
| SCHEMBL7085737 | 0.82 | LMNA (0.53) | LOXL2LOXSMN1; SMN2MEN1KMT2A | |
| SCHEMBL25167089 | 0.81 | MEN1 (0.57) | LOXL2LOXMAOBSMN1; SMN2RAB9A | |
| SCHEMBL28053751 | 0.81 | SCN9A (0.59) | LOXL2LOXMAOBSMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL27760678 | 0.81 | ASIC3 (0.42) | LOXL2LOXASIC3SMN1; SMN2MEN1 | |
| SCHEMBL8285845 | 0.81 | LOXL2 (0.57) | LOXL2LOXSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28350627 | 0.79 | LOXL2 (0.56) | LOXL2LOXMAOBSMN1; SMN2NPC1 | |
| SCHEMBL15055322 | 0.79 | RAB9A (0.62) | LOXL2LOXSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13452514 | 0.78 | LOXL2 (0.47) | LOXL2LOXSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7240848 | 0.78 | MAOB (0.49) | LOXL2LOXMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812056-B | N-pyridine-4-yl benzamide Cdc37 inhibitor and derivative and application thereof | 中国药科大学 | 2023-01-31 | — | — | CN | disclosed |
| CN-112812056-A | N-pyridin-4-ylbenzamide Cdc37 inhibitors, derivatives thereof and uses thereof | 中国药科大学 | 2021-05-18 | — | — | CN | disclosed |
| US-8586617-B2 | Aminomethyl-4-imidazoles | HOFFMANN-LA ROCHE INC. (US) | 2013-11-19 | — | — | US | disclosed |
| CN-101528710-B | Aminomethyl-4-imidazoles | HOFFMANN LA ROCHE | 2012-11-07 | — | — | CN | disclosed |
| EP-2076497-B1 | AMINOMETHYL-4-IMIDAZOLES | HOFFMANN LA ROCHE (CH) | 2012-02-22 | — | — | EP | disclosed |
| EP-2076497-A1 | AMINOMETHYL-4-IMIDAZOLES | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| US-20080119535-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-22 | — | — | US | disclosed |
| WO-2008046757-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119535-A1 | AMINOMETHYL-4-IMIDAZOLES | INMT, HTR4, MC4R | LOXL2 4234/4885LOX 2926/4885MAOB 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.