Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592864 | 0.88 | NQO2 (0.38) | NPC1RAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL6321843 | 0.87 | NPC1 (0.38) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL6320203 | 0.80 | RAB9A (0.37) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL7161966 | 0.75 | NPC1 (0.35) | NPC1RAB9AALDH1A1MAPTPTGER3 | |
| SCHEMBL7594183 | 0.75 | HSP90AA1 (0.37) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL7596886 | 0.74 | NQO2 (0.36) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL6321851 | 0.73 | KDM4E (0.36) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL7594464 | 0.71 | NQO2 (0.36) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7642818 | 0.70 | ALDH1A1 (0.34) | ALDH1A1MAPTHTTHSD17B10SMN1; SMN2 | |
| SCHEMBL7592861 | 0.68 | NPC1 (0.37) | NPC1RAB9AALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977246-B2 | Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency | INSPIRE PHARMACEUTICALS, INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-6946128-B1 | Protease conjugates having sterically protected epitope regions | THE PROCTER & GAMBLE COMPANY (US) | 2005-09-20 | — | — | US | disclosed |
| US-6348589-B1 | INCREASE THE HYDRATION OF RETAINED MUCUS SECRETIONS, STIMULATE THE PRODUCTION OF MUCINS; TREATING CHRONIC BRONCHITIS, CYSTIC FIBROSIS AND PNEUMONIA | INSPIRE PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |