Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.62 |
| ▸ | MMP2 | P08253 | 6/20 | 0.62 |
| ▸ | MMP8 | P22894 | 5/20 | 0.62 |
| ▸ | MMP13 | P45452 | 5/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6322381 | 0.85 | TAS2R14 (0.64) | MMP9MMP2MMP8CNR2HTT | |
| SCHEMBL6322368 | 0.78 | CNR2 (0.58) | MMP9MMP2MMP8MMP13ADAM17 | |
| SCHEMBL28940689 | 0.78 | CNR2 (0.54) | MMP9MMP2MMP8MMP13ADAM17 | |
| SCHEMBL13640662 | 0.77 | MMP9 (0.62) | MMP9MMP2MMP8MMP13ADAM17 | |
| SCHEMBL13640657 | 0.77 | MMP9 (0.62) | MMP9MMP2MMP8MMP13ADAM17 | |
| SCHEMBL6322605 | 0.76 | CNR2 (0.58) | MMP9MMP13ADAM17PTPN1CNR2 | |
| SCHEMBL13640694 | 0.75 | MMP9 (0.56) | MMP9MMP2MMP8MMP13ADAM17 | |
| SCHEMBL29422536 | 0.74 | MMP2 (1.00) | MMP9MMP2MMP8MMP13ADAM17 | |
| SCHEMBL7343979 | 0.72 | KEAP1 (0.81) | MMP9MMP2MMP8TAS2R14BMP1 | |
| SCHEMBL6325795 | 0.72 | TAS2R14 (0.61) | MMP9MMP2MMP8MMP13CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |
| EP-0939629-A4 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0939629-A1 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003166-A1 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | MMP9 11/4885MMP2 26/4885MMP8 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.