Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.57 |
| ▸ | ADH5 | P11766 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067002 | 0.89 | CYP19A1 (0.55) | CYP19A1CYP3A4BAZ2BADH5HTT | |
| SCHEMBL10574724 | 0.86 | CYP3A4 (0.74) | CYP3A4BAZ2BADH5HTTHTR2A | |
| SCHEMBL10756652 | 0.82 | CYP19A1 (0.56) | CYP19A1CYP3A4BAZ2BADH5HTT | |
| SCHEMBL27910907 | 0.81 | CYP51A1 (0.50) | CYP19A1CYP3A4BAZ2BADH5LMNA | |
| SCHEMBL328169 | 0.81 | HSPB1 (0.49) | CYP19A1CYP3A4LMNAENPP2MKNK1 | |
| SCHEMBL5836351 | 0.81 | CYP19A1 (0.48) | CYP19A1CYP3A4BAZ2BADH5HTT | |
| SCHEMBL608826 | 0.80 | ADH5 (0.67) | L3MBTL1CYP19A1CYP3A4BAZ2BADH5 | |
| SCHEMBL27778716 | 0.80 | ADH5 (0.57) | CYP19A1CYP3A4BAZ2BADH5HTT | |
| SCHEMBL5307055 | 0.79 | MAOB (0.67) | CYP3A4BAZ2BADH5HTTHTR2A | |
| SCHEMBL6324509 | 0.79 | MAPT (0.74) | CYP19A1CYP3A4BAZ2BADH5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | L3MBTL1 2991/4885CYP19A1 95/4885CYP3A4 369/4885 |
| US-20050113438-A1 | Substituted indoles | IDO2, IDO1, INMT | L3MBTL1 1992/4885CYP19A1 296/4885CYP3A4 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.