Sugi Predict

Sugi Predict / Compounds / SCHEMBL6325826

SCHEMBL6325826

SCHEMBL6325826

CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](CNC(=O)OC(C)(C)C)Cc1csc2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSS P25774 3/20 0.51
▸ CTSL P07711 2/20 0.51
▸ CTSK P43235 2/20 0.51
▸ OPRM1 P35372 2/20 0.41
▸ OPRD1 P41143 2/20 0.41
▸ OPRK1 P41145 2/20 0.41
▸ PTPRB P23467 2/20 0.40
▸ MMP9 P14780 3/20 0.40
▸ MMP2 P08253 2/20 0.40
▸ MMP8 P22894 2/20 0.40
▸ SYK P43405 1/20 0.39
▸ CTSB P07858 1/20 0.38
▸ TACR1 P25103 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ TP53 P04637 2/20 0.36
▸ CASP1 P29466 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ RXFP1 Q9HBX9 1/20 0.35
▸ MMP1 P03956 1/20 0.35
▸ MMP3 P08254 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6319683 0.89 OPRM1 (0.44) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6317169 0.88 CTSL (0.43) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6325830 0.84 CTSL (0.48) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6318037 0.83 CTSS (0.48) CTSSCTSLCTSKPTPRBSYK
SCHEMBL6319011 0.83 TAAR1 (0.39) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6317172 0.79 CTSL (0.44) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6317166 0.79 CTSL (0.44) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6317894 0.79 MMP2 (0.48) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6319054 0.79 MMP2 (0.48) CTSSCTSLCTSKOPRM1OPRD1
SCHEMBL6319686 0.79 MMP2 (0.44) CTSSCTSLCTSKOPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6939880-B2 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2005-09-06 — — US disclosed
US-6555570-B2 Growth hormone secretagogous with improved bioavailability NOVO NORDISK A/S (DE) 2003-04-29 — — US disclosed
US-20030055261-A1 Compounds with growth hormone releasing properties HELSINN THERAPEUTICS (U.S.), INC. 2003-03-20 — — US disclosed
US-6127391-A A PEPTIDE MIMETIC COMPOUND FOR STIMULATING THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY NOVO NORDISK A/S (DK) 2000-10-03 — — US disclosed
US-5977178-A Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 1999-11-02 — — US disclosed
EP-0869974-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1998-10-14 — — EP disclosed
WO-1997023508-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-07-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030055261-A1 Compounds with growth hormone releasing properties GHRHR, GHSR, IGFBP1 CTSS 2319/4885CTSL 1294/4885CTSK 1324/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.