Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801531 | 0.98 | LMNA (0.49) | LMNAMAPTSMN1; SMN2CYP4Z1HRH2 | |
| SCHEMBL11133611 | 0.89 | F11 (0.47) | LMNAMAPTSMN1; SMN2CYP4Z1HRH2 | |
| SCHEMBL27567003 | 0.83 | GAA (0.53) | LMNAMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL68851 | 0.80 | CYP4Z1 (0.62) | LMNAMAPTSMN1; SMN2CYP4Z1RAB9A | |
| SCHEMBL15955709 | 0.79 | KMT2A (0.60) | LMNAMAPTSMN1; SMN2CYP4Z1RAB9A | |
| SCHEMBL2245806 | 0.79 | RAB9A (0.65) | LMNAMAPTSMN1; SMN2HRH2HRH1 | |
| SCHEMBL21402770 | 0.79 | F11 (0.40) | HRH2HRH1RAB9ANPC1 | |
| SCHEMBL13084751 | 0.77 | NPC1 (0.49) | LMNAMAPTRAB9ANPC1KMT2A | |
| SCHEMBL6393097 | 0.77 | ALDH1A1 (0.57) | LMNAMAPTSMN1; SMN2CYP4Z1RAB9A | |
| SCHEMBL393094 | 0.77 | LMNA (0.55) | LMNAMAPTSMN1; SMN2CYP4Z1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. | 2004-08-26 | — | — | US | disclosed |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | LING KAH HIING (US) | 2003-04-03 | — | — | US | disclosed |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | LING KAH HIING (US) | 2002-02-07 | — | — | US | disclosed |
| EP-0871614-A1 | ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS | HOECHST MARION ROUSSEL, INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1996035667-A1 | ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS | Hoescht Marion Roussel, Inc. (US) | 1996-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | LMNA 4788/4885MAPT 4256/4885SMN1; SMN2 4785/4885 |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | HRH4, HRH2, HRH1 | LMNA 4739/4885MAPT 4354/4885SMN1; SMN2 4755/4885 |
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | LMNA 4788/4885MAPT 4256/4885SMN1; SMN2 4785/4885 |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | HRH4, HRH2, HRH1 | LMNA 4787/4885MAPT 4212/4885SMN1; SMN2 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.