Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 6/20 | 0.65 |
| ▸ | MMP2 | P08253 | 9/20 | 0.61 |
| ▸ | MMP9 | P14780 | 7/20 | 0.61 |
| ▸ | MMP13 | P45452 | 3/20 | 0.61 |
| ▸ | MMP3 | P08254 | 2/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | MMP7 | P09237 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326385 | 1.00 | ADAMTS4 (0.65) | ADAMTS4MMP2MMP9MMP13MMP3 | |
| SCHEMBL31310984 | 0.90 | SMN1; SMN2 (0.67) | ADAMTS4MMP2MMP9MMP13MMP3 | |
| SCHEMBL31310982 | 0.90 | SMN1; SMN2 (0.67) | ADAMTS4MMP2MMP9MMP13MMP3 | |
| SCHEMBL20021999 | 0.85 | MMP2 (0.63) | ADAMTS4MMP2MMP9MMP13MMP3 | |
| SCHEMBL18649869 | 0.83 | MMP2 (0.67) | ADAMTS4MMP2MMP9MMP13MMP3 | |
| SCHEMBL16519485 | 0.81 | CA2 (0.68) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL4752500 | 0.81 | CA2 (0.68) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6324016 | 0.81 | ADAMTS4 (0.53) | ADAMTS4CA12CA1CA2CA9 | |
| SCHEMBL16519484 | 0.81 | CA2 (0.68) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6324018 | 0.81 | ADAMTS4 (0.53) | ADAMTS4CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | ADAMTS4 33/4885MMP2 26/4885MMP9 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.