Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 13/20 | 0.51 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.45 |
| ▸ | NPY1R | P25929 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890529 | 0.82 | TGFBR1 (0.53) | NPY5R | |
| SCHEMBL6348344 | 0.78 | SLC6A9 (0.55) | SLC6A9PREPNPY5R | |
| SCHEMBL21752762 | 0.77 | DPP4 (0.56) | NPY5RKDM1A | |
| SCHEMBL4616003 | 0.76 | SFRP1 (0.64) | — | |
| SCHEMBL6340184 | 0.76 | ACACB (0.52) | — | |
| SCHEMBL5164618 | 0.76 | KDM1A (0.51) | KDM1A | |
| SCHEMBL8899787 | 0.75 | TGFBR1 (0.64) | NPY5RNPY1R | |
| SCHEMBL8899558 | 0.75 | ACKR3 (0.53) | SLC6A9NPY5RNPY1R | |
| SCHEMBL11969924 | 0.75 | KDM1A (0.55) | KDM1A | |
| SCHEMBL7417144 | 0.74 | KDM1A (0.45) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |