Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012150 | 0.85 | ALDH1A1 (0.43) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL8010394 | 0.81 | ALDH1A1 (0.45) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL12838390 | 0.80 | HDAC3 (0.58) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL2653117 | 0.79 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL7077550 | 0.79 | LMNA (0.51) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL4675103 | 0.79 | ALOX5 (0.47) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL7018973 | 0.78 | HDAC3 (0.73) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL6848383 | 0.78 | HDAC3 (0.55) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL6814615 | 0.78 | HDAC3 (0.55) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL1889333 | 0.77 | TDP1 (0.51) | HDAC3HDAC4HDAC1HDAC6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023246876-A1 | MEDICAL USE OF FORMAMIDE DERIVATIVES, FORMAMIDE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 上海科技大学 | 2023-12-28 | — | — | WO | disclosed |
| CN-117285520-A | Medical use of carboxamide derivative, carboxamide derivative and pharmaceutical composition containing carboxamide derivative | 上海科技大学 | 2023-12-26 | — | — | CN | disclosed |
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | AVENTIS PHARMA S.A. (FR) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | CTSZ, CTSE, CTSS | HDAC3 156/4885HDAC4 180/4885HDAC1 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.