Malotilate

Malotilate

SCHEMBL635496

CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 1/20 1.00
PDE4D Q08499 1/20 1.00
SMN1; SMN2 Q16637 2/20 0.36
GAA P10253 1/20 0.36
TSHR P16473 2/20 0.36
CA12 O43570 6/20 0.34
CA1 P00915 6/20 0.34
CA2 P00918 6/20 0.34
CA7 P43166 6/20 0.34
CA9 Q16790 6/20 0.34
CA14 Q9ULX7 6/20 0.34
KDM4E B2RXH2 1/20 0.32
BCHE P06276 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
MEN1 O00255 2/20 0.30
KMT2A Q03164 2/20 0.30
TUBB4A P04350 1/20 0.30
TUBB P07437 1/20 0.30
TUBA3C P0DPH7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8055886 0.90 ADRA1A (0.82) ADRA1APDE4DSMN1; SMN2GAATSHR
SCHEMBL9706734 0.89 ADRA1A (0.79) ADRA1APDE4DSMN1; SMN2GAATSHR
SCHEMBL8050522 0.88 ADRA1A (0.77) ADRA1APDE4DSMN1; SMN2GAATSHR
Malotilate SCHEMBL5489569 0.87 ADRA1A (0.75) ADRA1APDE4D
SCHEMBL9706745 0.87 ADRA1A (0.75) ADRA1APDE4DMEN1KMT2A
SCHEMBL10614796 0.87 ADRA1A (0.75) ADRA1APDE4D
SCHEMBL9706771 0.86 ADRA1A (0.74) ADRA1APDE4DSMN1; SMN2GAACA12
SCHEMBL9706732 0.84 ADRA1A (0.72) ADRA1APDE4DSMN1; SMN2GAATSHR
SCHEMBL9674608 0.83 ADRA1A (0.69) ADRA1APDE4DTSHR
SCHEMBL9706767 0.82 ADRA1A (0.68) ADRA1APDE4DBCHEMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1003 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA PLUTO INC (KR) 2025-10-30 US claimed
US-12385916-B2 Serum metabolic biomarkers and kit for detecting drug-resistant tuberculosis Zhejiang SUKEAN Pharmaceutical Co., Ltd. (CN) 2025-08-12 US claimed
EP-4494639-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA Pluto Inc. (KR) 2025-01-22 EP claimed
CN-119325992-A Broad-spectrum plant fungus bactericide 华中农业大学 2025-01-21 CN claimed
US-12196753-B2 Kit for detecting drug-resistant tuberculosis Zhejiang SUKEAN Pharmaceutical Co., Ltd. (CN) 2025-01-14 US claimed
US-20240295555-A1 KIT FOR DETECTING DRUG-RESISTANT TUBERCULOSIS Zhejiang SUKEAN Pharmaceutical Co., Ltd. (CN) 2024-09-05 US claimed
US-20240108644-A1 TUMOR IMMUNOTHERAPY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2024-04-04 US claimed
US-20230349900-A1 SERUM METABOLIC BIOMARKERS AND KIT FOR DETECTING DRUG-RESISTANT TUBERCULOSIS Zhejiang SUKEAN Pharmaceutical Co., Ltd. (CN) 2023-11-02 US claimed
CN-114432334-B Application of lnc-BIHAA1 in preparation of medicines for preventing and/or treating hepatic fibrosis 中山大学附属第三医院 2023-10-24 CN claimed
WO-2023177128-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA 주식회사 플루토 2023-09-21 WO claimed
WO-1995001096-A1 PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR TREATMENT OF NEUROLOGICAL DISEASES AND ETIOLOGICALLY RELATED SYMPTOMOLOGY SHAPIRO HOWARD K (US) 1995-01-12 WO claimed
EP-0134112-B1 PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS OR TREATMENT OF KETOSIS IN LIVESTOCK NIHON NOHYAKU CO., LTD. (JP) 1991-04-03 EP claimed
US-5001143-A Pharmaceutical composition for prophylactic and preventive of ketosis of livestocks NIHON NOHYAKU CO., LTD. (JP) 1991-03-19 US claimed
EP-0238726-A2 1,3-Dithio-2-ylidene malonates for curing fat necrosis NIHON NOHYAKU CO., LTD. (JP) 1987-09-30 EP claimed
EP-0237472-A2 An ameliorating agent for pulmonary fibrosis and the use thereof Zyma SA (CH) 1987-09-16 EP claimed
EP-0103206-B1 FEED COMPOSITION NIHON NOHYAKU CO., LTD. (JP) 1986-11-26 EP claimed
EP-0134112-A2 Pharmaceutical composition for prophylaxis or treatment of ketosis in livestock NIHON NOHYAKU CO., LTD. (JP) 1985-03-13 EP claimed
EP-0103206-A1 Feed composition NIHON NOHYAKU CO., LTD. (JP) 1984-03-21 EP claimed
US-4118506-A LIVER DISORDERS NIHON NOHYAKU CO., LTD. (JP) 1978-10-03 US claimed
US-4035387-A FUNGICIDE NIHON NOHYAKU CO. LTD. (JA) 1977-07-12 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA MYOF, ALOX5, MYLK2 ADRA1A 1161/4885PDE4D 2626/4885SMN1; SMN2 309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.