Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6356674 | 0.89 | KMT2A (0.57) | LMNAL3MBTL1MAPTSGMS2HPGD | |
| SCHEMBL6357846 | 0.89 | SGMS2 (0.61) | LMNAL3MBTL1MAPTPLA2G1BATG4B | |
| SCHEMBL6355643 | 0.88 | HPGD (0.54) | LMNAL3MBTL1MAPTPLA2G1BATG4B | |
| SCHEMBL6355280 | 0.86 | LMNA (0.55) | LMNAMAPTPLA2G1BATG4BSGMS2 | |
| SCHEMBL6354502 | 0.84 | KMT2A (0.54) | LMNAMAPTSGMS2HPGDSMN1; SMN2 | |
| SCHEMBL6354409 | 0.83 | NPC1 (0.56) | LMNAL3MBTL1MAPTPLA2G1BATG4B | |
| SCHEMBL6355252 | 0.82 | SGMS2 (0.61) | LMNAL3MBTL1MAPTSGMS2HPGD | |
| SCHEMBL6360998 | 0.81 | KMT2A (0.60) | LMNAL3MBTL1MAPTSGMS2HPGD | |
| SCHEMBL6355111 | 0.80 | ALDH1A1 (0.58) | LMNAL3MBTL1MAPTSGMS2HPGD | |
| SCHEMBL6354467 | 0.79 | PTGER1 (0.55) | MAPTSGMS2HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009812-A1 | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-01-13 | — | — | US | claimed |
| EP-1438973-A1 | REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-07-21 | — | — | EP | claimed |
| US-20080194620-A1 | Use of Benzodiazepine Receptor Ligands For Combating Signs of Ageing | L'OREAL (FR) | 2008-08-14 | — | — | US | disclosed |
| US-20080194620-A1 | Use of Benzodiazepine Receptor Ligands For Combating Signs of Ageing | L'OREAL (FR) | 2008-08-14 | — | — | US | disclosed |
| US-20050009812-A1 | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| EP-1438973-A1 | REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009812-A1 | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists | TFAM, CYP11B2, CYP11B1 | LMNA 1197/4885L3MBTL1 2120/4885MAPT 1231/4885 |
| US-20080194620-A1 | Use of Benzodiazepine Receptor Ligands For Combating Signs of Ageing | GABBR1, GABBR2, GABRA2 | LMNA 1188/4885L3MBTL1 3519/4885MAPT 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.